Development and physicochemical characterization of chitosan hydrochloride/sulfobutyl ether‐β‐cyclodextrin nanoparticles for cinnamaldehyde entrapment

Abstract

In this work, the cinnamaldehyde (CA) loaded nanoparticles were synthesized by directly cross‐linking chitosan hydrochloride (CSH) and sulfobutyl ether‐β‐cyclodextrin (SBE‐β‐CD). The CA/SBE‐β‐CD inclusion complex was firstly prepared, and its highest encapsulation efficiency (EE) was 86.34%. Field Emission Scanning Electron Microscope results indicated that the inclusion complex showed massive aggregates with a coarse and fluffy texture and irregular surface. Then, the inclusion complex interacted with CSH to form nanoparticles. The EE of CA in nanoparticles was improved. Atomic force microscopy showed the nanoparticles had regular and spherical morphology. Fourier transform infrared spectroscopy analysis demonstrated that CA was mainly encapsulated in the inner place of CSH/SBE‐β‐CD nanoparticles (CSNs). The enhanced thermal stability of the nanoparticles was found in differential scanning calorimeter. X‐ray diffraction implied that CA‐CSNs existed in the amorphous state. CA‐CSNs had excellent slow release property. Further, the bacteriostatic effect of CA‐CSNs was much better than that of CA and CSNs. All the results indicated that CSNs can be used as a promising carrier to encapsulate CA. Practical applications CA is an effective antimicrobial and generally recognized as Safe‐GRAS. CA also exhibits many other bioactivities and has been commonly used for digestive, cardiovascular and immune system diseases. However, CA is easy to be oxidized and volatilized during storage for poor water solubility. The nanoencapsulations display the capacities of enhancing solubility of bioactive compounds, protecting them from degradation, and prolonging their residence. In this manuscript, CA loaded nanoparticles were investigated. The results suggested that the nanoencapsulation could benefit for improving water solubility and stability of CA. This strategy could be helpful for its application and development in food preservation.

Gellan Gum- And Pectin-Magnetic Graphene Oxide Nanocarriers Loaded With Cinnamaldehyde for Mosquito Larvae Control

“…Spherical nanocomposites are observed following cinnamaldehyde loading into GG-GO-Fe3O4 (Figure 3(c)). Meanwhile, aggregation can be observed, in accordance with findings by Zhu et al [18], where the entrapment of cinnamaldehyde by chitosan hydrochloride/sulfobutyl ether cyclodextrin nanoparticles resulted in a coarse, fluffy, irregular surface. The PEC-GO-Fe3O4 nanocomposite presents a wrinkled structure after cinnamaldehyde is introduced into the system (Figure 3(d)), where the nanocomposites are aggregated and dispersed on the surface.…”

“…The PEC-GO-Fe3O4 nanocomposite presents a wrinkled structure after cinnamaldehyde is introduced into the system (Figure 3(d)), where the nanocomposites are aggregated and dispersed on the surface. PEC adsorption on the particles and the entrapment of particles by PEC gel results in large aggregations, and this may be caused by PEC network expansion at low ionic strengths or by steric hindrance of the chains [18,19].…”

Effect of cinnamon essential oil/γ‐cyclodextrin inclusion complex on papaya quality and shelf‐life

“…14,15 Cyclodextrin (CD) is a cyclic oligosaccharide comprising 6, 7, and 8 (⊍-1,4)-linked ⊍-D-glucopyranose units (⊍, ⊎, and γ-CD, respectively). 16 Cyclodextrins possess a lipophilic property within their central cavities and a hydrophilic property on their outer surfaces. 17 This unique characteristic allows them to encapsulate hydrophobic substances in their central cavities, providing protection against environmental factors, reducing taste and odor, and controlling the sustained release of these guest molecules.…”

Curcumin Encapsulated in Crosslinked Cyclodextrin Nanoparticles Enables Immediate Inhibition of Cell Growth and Efficient Killing of Cancer Cells

“…Thus, cyclodextrins are valued for improving the solubility of many drugs, for minimizing detrimental side effects by forming host-guest inclusion compounds and furthermore for stabilizing drugs against premature degradation, thus consequently increasing their bioavailability. CD-based formulations are prepared using different strategies [13], usually based on forming a spontaneous self-assembly of drug and CD units into aggregates [14], the assembly process often being aided by polymers [15] or by polymer-functionalized CD derivatives (e.g., through ionotropic gelation [16,17]), or by attaching cyclodextrins to nanoparticle (NP) scaffolds such as Au-NP or silica NP [6,10,14,[18][19][20][21]. Supramolecular assemblies with high surface areas were developed as CD metal organic frameworks (CD-MOF) [22].…”