Development and pharmacological evaluation of in vitro nanocarriers composed of lamellar silicates containing copaiba oil-resin for treatment of endometriosis

Borges, Vinícius Raphael de Almeida; Silva, Julianna Henriques da; Barbosa, Samantha Soares; Nasciutti, Luiz Eurico; Cabral, Lúcio Mendes; Sousa, Valéria Pereira de

doi:10.1016/j.msec.2016.03.094

Cited by 19 publications

(6 citation statements)

References 46 publications

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“…The oral administration of copaiba has been used as another form of alternative therapy with controversial results. With 28.6%, in the present meta-analysis, the oral administration of copaiba has been shown to be an effective agent against certain parasites, 14 gastrointestinal cancer, 8 6,7,15 arthritis, 16 and other conditions. Contrary to what was thought, the oral administration of copaiba was shown to be non-toxic to rat liver when used as a carrier for amphotericin B.…”

Section: Resultsmentioning

confidence: 72%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

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Section: Resultsmentioning

confidence: 72%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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“…2A, free DETC presents characteristic peaks at 837, 909, 985 cm -1 (CeS), 1070, 2104 (C]S) and 1423 cm −1 N-CS 2 ) [11,40,41]. Copaiba oil presents a characteristic peak at 1740 cm -1 (C] O) and a broad medium band between 3100 and 2700 cm -1 , attributed to carboxylic acids [42,43]. In the FTIR spectra of beeswax, it was observed peaks at 2922, 2848 cm -1 (stretching vibrations of CeH groups), 1736 cm −1 (stretching vibrations of the carbonyls of esters), 1467 cm -1 (hydrocarbon vibrations) and peaks located at 1300 to 728 cm -1 related to the ester group [44,45].…”

Section: Resultsmentioning

confidence: 99%

Diethyldithiocarbamate loaded in beeswax-copaiba oil nanoparticles obtained by solventless double emulsion technique promote promastigote death in vitro

Mazur

Feuser

Valério

et al. 2019

Colloids and Surfaces B: Biointerfaces

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Leishmaniasis is considered a neglected tropical disease that represents a Public Health problem due to its high incidence. In the search of new alternatives for Leishmaniasis treatment diethyldithiocarbamate (DETC) has shown an excellent leishmanicidal activity and the incorporation into drug carrier systems, such as solid lipid nanoparticles (SLNs), is very promising. In the present work DETC loaded in beeswax nanoparticles containing copaiba oil were obtained by the double emulsion/melt technique. The nanoparticles were characterized and leishmanicidal activity against L. amazonensis promastigotes forms and cytotoxicity in murine macrophages were evaluated. SLNs presented size below 200 nm, spherical morphology, negative charge surface, high encapsulation efficiency, above 80%, and excellent stability. Moreover, Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analyses were performed to evaluate the chemical structure and possible interactions between DETC and SLNs. SLNs provided a protection for DETC, decreasing its cytotoxic effects in macrophages, which led to an improvement in the selectivity against the parasites, which almost doubled from free DETC (11.4) to DETC incorporated in SLNs (18.2). These results demonstrated that SLNs had a direct effect on L. amazonensis promastigotes without affect the viability of macrophage cell, can be a promising alternative therapy for the cutaneous treatment of L. amazonensis

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“…[ 200 ] Therefore, several research groups proposed that encapsulating copaiba oil extracts within nanomaterials may provide advantages for their bioavailability, delivery, safety, and therapeutic effect. [ 43,45,44 ]…”

Section: Nanoparticle‐based Treatment Modalitiesmentioning

confidence: 99%

“…In contrast to CPO‐loaded PLGA nanoparticles, the same research group demonstrated that copaiba oleoresin encapsulated in a non‐toxic lamellar silicate nanocomposite (Viscogel B8, VB8) significantly reduces the cell viability and proliferation of all three endometrial cell lines (CESCs, EuESCs, and EctESCs). [ 43 ] Moreover, the observed therapeutic effect of COPA nanocomposites was the most pronounced in the endometrial stromal cells obtained from endometriotic lesions (EctESCs). For example, a 60% reduction in proliferation of EctESCs was observed when treated with 300 µg mL −1 VB8 COPA nanocomposite, while the proliferation of CESCs and EuSCs decreased by 20% and 35%, respectively, with the same formulation and concentration.…”

Section: Nanoparticle‐based Treatment Modalitiesmentioning

confidence: 99%

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

Moses

Demessie

Taratula

et al. 2021

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Endometriosis is an incurable gynecological disease characterized by the abnormal growth of endometrium‐like tissue, characteristic of the uterine lining, outside of the uterine cavity. Millions of people with endometriosis suffer from pelvic pain and infertility. This review aims to discuss whether nanomedicines that are promising therapeutic approaches for various diseases have the potential to create a paradigm shift in endometriosis management. For the first time, the available reports and achievements in the field of endometriosis nanomedicine are critically evaluated, and a summary of how nanoparticle‐based systems can improve endometriosis treatment and diagnosis is provided. Parallels between cancer and endometriosis are also drawn to understand whether some fundamental principles of the well‐established cancer nanomedicine field can be adopted for the development of novel nanoparticle‐based strategies for endometriosis. This review provides the state of the art of endometriosis nanomedicine and perspective for researchers aiming to realize and exploit the full potential of nanoparticles for treatment and imaging of the disorder.

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Development and pharmacological evaluation of in vitro nanocarriers composed of lamellar silicates containing copaiba oil-resin for treatment of endometriosis

Cited by 19 publications

References 46 publications

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Diethyldithiocarbamate loaded in beeswax-copaiba oil nanoparticles obtained by solventless double emulsion technique promote promastigote death in vitro

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

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