Development and pharmacokinetics evaluation of quetiapine fumarate sustained-release tablets based on hydrophilic matrix

Zhang, Xuejuan; Li, Yongcheng; Huang, Zhengwei; Cui, Yingtong; Zhao, Ziyu; Xiao, Yumei; Wang, Guanlin; Liang, Ruifeng; Huang, Ying; Tan, Wen; Wu, Chuanbin

doi:10.1016/j.jddst.2019.101322

Cited by 7 publications

(3 citation statements)

References 53 publications

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“…This finding indicates that HPMC better facilitates the slower release of EFB-H to the corrosive solution. HPMC is excellent in slowing down the disintegration due to its high hydrophilicity, enabling the polymer to swell and become gelatinised upon contact with water [ 82 ]. The formation of the polymer gel retards the diffusion of active ingredients and the tablet’s erosion.…”

Section: Resultsmentioning

confidence: 99%

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

et al. 2021

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This study aims to develop a controlled release oil palm empty fruit bunch hemicellulose (EFB-H) inhibitor tablet for mild steel in 1 M HCl. As plant extracts tend to deteriorate at longer immersion time, limiting its industrial applicability, we attempted to lengthen the inhibition time by forming a controlled release inhibitor tablet. Electrochemical methods (potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS)) were employed to investigate the efficiency and mechanism of the inhibition. An optimum dosage and immersion time was determined via Response Surface Methodology (RSM). EFB-H tablet was formulated using D-optimal mixture design, and its anticorrosion action at extended immersion time was compared with EFB-H powder. PDP measurement revealed that EFB-H is a mixed type inhibitor. RSM optimization unveiled that the optimum point for a maximum inhibition efficiency (87.11%) was at 0.33 g of EFB-H and 120 h of immersion time. Tablet T3 with EFB-H to gum Arabic to hydroxypropyl methylcellulose ratio of 66:0:34 portrayed the best tensile strength (0.243 MPa), disintegration time (152 min) and dissolution behavior. EFB-H tablet exhibited a longer-lasting inhibition effect than powder, which was 360 h as compared to 120 h for powder. Overall, EFB-H tablet has been successfully developed, and its enhanced effective inhibition time has been experimentally proven.

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Section: Resultsmentioning

confidence: 99%

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

et al. 2021

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“…The similarity factor (f 2 ) was calculated to compare the release profiles of the IMM-H014 ER tablets during the production and stability study periods, which were defined by Equation ( 6) [24].…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

“…where n is the number of sampling times, and R t and T t are the dissolution values of the reference and test samples at each timing, respectively [24].…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Development and In Vitro–In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease

Zhang

Shao

Han

et al. 2023

IJMS

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This study aimed to develop extended-release tablets containing 25 mg IMM-H014, an original drug formulated by a direct powder pressing method based on pharmaceutical-grade hydrophilic matrix polymers such as hydroxypropyl methylcellulose, to establish an in vitro–in vivo correlation (IVIVC) to predict bioavailability. The tablets’ mechanical properties and in vitro and in vivo performance were studied. The formulation was optimized using a single-factor experiment and the reproducibility was confirmed. The in vitro dissolution profiles of the tablet were determined in five dissolution media, in which the drug released from the hydrophilic tablets followed the Ritger–Peppas model kinetics in 0.01 N HCl medium for the first 2 h, and in phosphate-buffered saline medium (pH 7.5) for a further 24 h. Accelerated stability studies (40 °C, 75% relative humidity) proved that the optimal formulation was stable for 6 months. The in vivo pharmacokinetics study in beagle dogs showed that compared to the IMM-H014 immediate release preparation, the maximum plasma concentration of the extended-release (ER) preparation was significantly decreased, while the maximum time to peak and mean residence time were significantly prolonged. The relative bioavailability was 97.9% based on the area under curve, indicating that the optimal formulation has an obvious ER profile, and a good IVIVC was established, which could be used to predict in vivo pharmacokinetics based on the formulation composition.

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Robustness of Controlled Release Tablets Based on a Cross-linked Pregelatinized Potato Starch Matrix

et al. 2020

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Development and pharmacokinetics evaluation of quetiapine fumarate sustained-release tablets based on hydrophilic matrix

Cited by 7 publications

References 53 publications

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

Innovative Method for Longer Effective Corrosion Inhibition Time: Controlled Release Oil Palm Empty Fruit Bunch Hemicellulose Inhibitor Tablet

Development and In Vitro–In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease

Robustness of Controlled Release Tablets Based on a Cross-linked Pregelatinized Potato Starch Matrix

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