Development and optimization of an ultra-fast microextraction followed by HPLC-UV of tetracycline residues in milk products

Zergiebel, Stephanie; Ueberschaar, Nico; Seeling, Andreas

doi:10.1016/j.foodchem.2022.134270

Cited by 19 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a broad-spectrum antibiotic, tetracycline (TC) is often used for clinical treatment, forestry, and animal husbandry, as well as animal medication. , However, the excessive abuse of TC aggravates the evolution of drug resistance and also poses a great risk to the ecological environment after discharged wastewater treatment. , The current detection methods of TC usually include HPLC, capillary electrophoresis, and electrochemistry. − Considering the experimental cost and the environmental contamination from a large volume of organic mobile phase of HPLC, as well as the poor reproducibility of electrochemistry, the fluorescent sensor is definitely the most promising detection method because of its convenience of operation and speed of detection . A variety of fluorescent sensors for the detection of TC have been reported, most of which are based on carbon quantum dots doped with N and S atoms. , These carbon dots have excitation-dependent fluorescence, which may be important for certain practical applications, but their relatively poor color purity and broad emission spectra seriously limited their practical application. , …”

Section: Introductionmentioning

confidence: 99%

Polyethyleneimine-Sulfur Quantum Dot Composites for Dual-Channel Detection of Tetracycline by Colorimetric and Fluorescence Sensing

Chang

Wei

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The residue of tetracycline from food and environment poses a potential threat to public health. Developing a more convenient portable optical detection system has become more demanding than fluorescence detection. This study describes a sensor of sulfur quantum dots (SQDs) with a positively charged passivator for tetracycline in the concentrations from 0.20 to 100 μM and a limit of detection of 0.15 μM (3σ/k). A new optical sensing device was also designed with a smartphone as the detector for sensing the color change from blue to yellow-green upon the addition of tetracycline. In the presence of Eu3+, the detectable color change is extended to red. The verification of the sensing device was applied to the real detection of lake water and milk, with a standard recovery from 93.1 to 109%. This emissive excitation-independent SQD first ensures a sensitive and accurate analysis at very low concentrations and also demonstrates evident color changes upon interaction with tetracycline. The application of this method has provided great convenience for practical detection.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyethyleneimine-Sulfur Quantum Dot Composites for Dual-Channel Detection of Tetracycline by Colorimetric and Fluorescence Sensing

Chang

Wei

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…The excessive use of tetracyclines can lead to high residues in food of animal origin, posing a risk to human health and public health. 1 Currently, common analytical methods applied for TC detection are high performance liquid chromatography (HPLC), 2,3 liquid chromatography-mass spectrometry (LC-MS), 4,5 enzyme-linked immunoassay (ELISA), 6,7 microbial inhibition, [8][9][10] and spectrophotometry. 11 However, these assays usually require expensive instruments, complex sample pre-treatment, and professional operators.…”

Section: Introductionmentioning

confidence: 99%

Construction of a dual-signal molecularly imprinted photoelectrochemical sensor based on bias potential control for selective sensing of tetracycline

2023

View full text Add to dashboard Cite

show abstract

“…Drug salt formation is a commonly used process to increase drug solubility during drug development [19]. High-purity TCH, a representative hydrochloride salt form of drug materials, can be employed as the primary reference material and calibrator in analytical measurements, such as monitoring it in foods [20,21]. The concentration of the standard solution can be corrected with well-assigned purity of the standard material and consequently the measured results are more accurate with the measurement traceability.…”

Section: Introductionmentioning

confidence: 99%

Analytical Methods Based on the Mass Balance Approach for Purity Evaluation of Tetracycline Hydrochloride

Lee,

Baek,

Kwon

et al. 2023

Molecules

View full text Add to dashboard Cite

Analytical methods based on the mass balance approach were developed for the purity evaluation of tetracycline hydrochloride, a representative salt compound used in pure veterinary drug analysis. The purity assignment method was used to quantify individual classes of impurities via independent analytical techniques. The mass fraction of the free base or salt form contained in a high-purity organic compound with a hydrochloride salt can be determined. The chloride content by ion chromatography-conductivity detector (IC-CD) and general classes of impurities, including structurally related impurities by liquid chromatography–ultraviolet (LC-UV) detector, water by Karl Fischer (KF) coulometric titration, residual solvents by headspace sampler gas chromatography/mass spectrometry (HS-GC/MS), and non-volatiles by thermogravimetric analyzer (TGA), were considered to calculate the purity of the mass fraction. The chloride content of the salt compound can be considered the main impurity in the mass fraction of the free base in the salt compound. A purity assay using quantitative nuclear magnetic resonance (q-NMR) as a direct determination method was performed to confirm the results of the mass balance method. The assigned purities of the tetracycline free form and its salt form in mass fraction were (898.80 ± 1.60) mg/g and (972.65 ± 1.58) mg/g, respectively, which are traceable to the international system of units (SI). Thus, the procedure for evaluating the purity of the free base and salt forms in the salt compound is newly demonstrated in this study.

show abstract

Development and optimization of an ultra-fast microextraction followed by HPLC-UV of tetracycline residues in milk products

Cited by 19 publications

References 29 publications

Polyethyleneimine-Sulfur Quantum Dot Composites for Dual-Channel Detection of Tetracycline by Colorimetric and Fluorescence Sensing

Polyethyleneimine-Sulfur Quantum Dot Composites for Dual-Channel Detection of Tetracycline by Colorimetric and Fluorescence Sensing

Construction of a dual-signal molecularly imprinted photoelectrochemical sensor based on bias potential control for selective sensing of tetracycline

Analytical Methods Based on the Mass Balance Approach for Purity Evaluation of Tetracycline Hydrochloride

Contact Info

Product

Resources

About