Development and Optimization of Acyclovir Loaded Mucoadhesive Microspheres by Box – Behnken Design

Karmoker, James Regun; Hasan, Ikramul; Ahmed, Nusrat; Saifuddin, Mohammad; Reza, Selim

doi:10.3329/dujps.v18i1.41421

Cited by 36 publications

(22 citation statements)

References 26 publications

(29 reference statements)

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“…Statistical methods such as RSM can be worked to capitalize on the production of a special substance by optimization of operational factors. Of late, for preparation optimization, the RSM, using an appropriate design of experiments, has become widely used [23]. In contrast to predictable methods, the communication among procedure variables can be resolute by statistical techniques [24].…”

Section: Methodsmentioning

confidence: 99%

A Review on Using ANOVA and RSM Modelling in The Glass Powder Replacement of The Concrete Ingredients

Neamat

Hassan

2021

JASTT

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The flat glass powder usage instead of sand is convenient in structurally serviceable and environmentally compatible concrete. The deposits of glass powder in fibres cement compounds manufacture may add significant technical, economic and environmental necessities. The cement material and cement replacement by glass powder is chosen as parameters of the concrete. When the waste glass is fined to very fine dust, it demonstrates a cementitious characteristic due to silica content. Statistical methods and techniques are heavily used in glass powder replacement. In this paper, fifteen papers are reviewed and investigated to check the availability of using the statistical and modelling system in discussing the glass powder replacement with some other ingredients results between 2012-2021. We found that most of the papers depended on the ANOVA test to perform their work. Moreover, central composite face-centred (CFC) and Response Surface Methodology (RSM) took a part in the studies. From the numerous replicas, a quadratic prototypical was supplied with waste glass powder in the numbers of the studies that the glass waste powder is the best with its characteristics.

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Section: Methodsmentioning

confidence: 99%

A Review on Using ANOVA and RSM Modelling in The Glass Powder Replacement of The Concrete Ingredients

Neamat

Hassan

2021

JASTT

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“…Statistical approaches such as the RSM can be employed to maximize the production of a special substance by optimizing the operational factors. Recently, the RSM alongside proper design of experiments has been extensively used for formulation optimization [26]. In contrast to conventional methods, the interaction among process variables can be determined using statistical techniques [27].…”

Section: Response Surface Methodology (Rsm)mentioning

confidence: 99%

Strategy for Surface Post-Processing of AISI 316L Additively Manufactured by Powder Bed Fusion Using Ultrasonic Nanocrystal Surface Modification

Cho

Kim

Pyun

et al. 2021

Metals

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Ultrasonic nanocrystal surface modification (UNSM) technology was applied to the surfaces of specimens additively manufactured by powder bed fusion (PBF). The changes in roughness and hardness due to the UNSM were set as objective functions, and the optimal conditions for the main parameters were derived through the response surface method (RSM) and Box–Behnken design (BBD). Regression analysis-based mathematical models for predicting the surface hardness and roughness are presented and validated. The RSM results show that the surface roughness is highly dependent on the load and ball tip diameter, and the surface roughness significantly improves as the inter-pass interval and ball tip diameter decrease. Through BBD and ANOVA, the optimal conditions for the improvement of surface characteristics were found to be a load of 40 N, inter-pass interval of 10 μm, and ball tip diameter of 2.38 m. The surface treated under these optimal conditions exhibited a hardness of 497 Hv and surface roughness of 1.32 μm, which were significantly improved compared to the values for an untreated specimen. In addition, it was confirmed that the grains are significantly refined after UNSM, and scratch resistance increases for the top layer of the surface directly affected by the UNSM horn.

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“…Clarithromycin (CM) containing microspheres were prepared by modification of emulsion and solvent evaporation method. 15 The microspheres preparation in three step process, in the first step solvent dispersed drug solution was mixed with previously aqueous reconstituted International Journal of Pharmaceutical Investigation, Vol 10, Issue 3, Jul-Sep, 2020 beta Cyclodextrin (βCD) solutions was propelled until the removal of solvent from the drug solution. Chitosan solubilised in 0.1% acetic acid solution also kept aside.…”

Section: Preparation Of Microspheres By Modified Emulsion -Lyophilisation Methodsmentioning

confidence: 99%

Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin

Subramanian

Rao²,

Selvamuthukumar

2020

IJPI

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Objectives:The present systematic research is to design, develop clarithromycin nasal mucoadhesive microspheres for the utilisation in respiratory tract infection as alternative route of drug delivery. Methods: Current study designed to formulate, evaluated by using chitosan, beta cyclodextrin with modified emulsion lyophilisation method. 2 4 factorial design was used in optimization technique. Characterisation of prepared microspheres will be subjected for particle size and size distribution, drug entrapment study, in vitro drug diffusion studies and ex vivo mucoadhesion, surface morphology, zeta potential, infra-red radiation, differential scanning calorimetry, X-ray diffraction and stability studies. Results: The optimised formulation of predicted values of chitosan 0.604, Beta cylclodextrin 0.7633, Propeller Mixing Speed 9369 and Lyocycle temperatue of -42.8°C, Particle Size 14.06 µm, Entrapment efficiency 73.32%, Mucoadhesion 81.03 % and Maximum drug release 80.56%. Other finding results were satisfactory in control of quality attributes. Conclusion: Developed microspheres can be potential highlight on utilisation of clarithromycin as nasal drug delivery with beneficial as alternative dosage form for respiratory tract infections.

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Development and Optimization of Acyclovir Loaded Mucoadhesive Microspheres by Box – Behnken Design

Cited by 36 publications

References 26 publications

A Review on Using ANOVA and RSM Modelling in The Glass Powder Replacement of The Concrete Ingredients

A Review on Using ANOVA and RSM Modelling in The Glass Powder Replacement of The Concrete Ingredients

Strategy for Surface Post-Processing of AISI 316L Additively Manufactured by Powder Bed Fusion Using Ultrasonic Nanocrystal Surface Modification

Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin

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