Development and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains

Révész, Dóra; Kuijk, Sander M. J. van; Mols, Floortje; Duijnhoven, Fränzel J.B. van; Winkels, Renate M.; Hoofs, Huub; Kant, IJmert; Smits, Luc; Breukink, Stéphanie O.; Poll‐Franse, Lonneke V. van de; Kampman, Ellen; Beijer, Sandra; Weijenberg, Matty P.; Bours, Martijn J.L.

doi:10.1186/s12911-020-1064-9

Cited by 13 publications

(13 citation statements)

References 52 publications

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“…Therefore, recognizing the potential impact of the above factors on patient well-being is crucial in understanding the context in which the study was conducted and the generalizability of the findings to other settings or time periods. According to previous studies, there were models to predict quality-of-life outcomes among patients with pancreatic cancer (28), cervical cancer survivors (29), colorectal cancer survivors (30,31), patients who underwent colorectal cancer surgery (32), and patients who underwent prostate radiation therapy (33)…”

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative health-related quality of life among patients with metastatic spinal cord compression secondary to lung cancer

Fu,

Shi,

Zhao

et al. 2023

Front. Endocrinol.

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BackgroundHealth-related quality of life (HRQoL) is a critical aspect of overall well-being for patients with lung cancer, particularly those with metastatic spinal cord compression (MSCC). However, there is currently a lack of universal evaluation of HRQoL in this specific patient population. The aim of this study was to develop a nomogram that can accurately predict HRQoL outcomes in patients with lung cancer-related MSCC.MethodsA total of 119 patients diagnosed with MSCC secondary to lung cancer were prospectively collected for analysis in the study. The least absolute shrinkage and selection operator (LASSO) regression analysis, along with 10-fold cross-validation, was employed to select the most significant variables for inclusion in the nomogram. Discriminative and calibration abilities were assessed using the concordance index (C-index), discrimination slope, calibration plots, and goodness-of-fit tests. Net reclassification index (NRI) and integrated discrimination improvement (IDI) analyses were conducted to compare the nomogram’s performance with and without the consideration of comorbidities.ResultsFour variables were selected to construct the final nomogram, including the Eastern Cooperative Oncology Group (ECOG) score, targeted therapy, anxiety scale, and number of comorbidities. The C-index was 0.87, with a discrimination slope of 0.47, indicating a favorable discriminative ability. Calibration plots and goodness-of-fit tests revealed a high level of consistency between the predicted and observed probabilities of poor HRQoL. The NRI (0.404, 95% CI: 0.074–0.734, p = 0.016) and the IDI (0.035, 95% CI: 0.004–0.066, p = 0.027) confirmed the superior performance of the nomogram with the consideration of comorbidities.ConclusionsThis study develops a prediction nomogram that can assist clinicians in evaluating postoperative HRQoL in patients with lung cancer-related MSCC. This nomogram provides a valuable tool for risk stratification and personalized treatment planning in this specific patient population.

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Section: Discussionmentioning

confidence: 99%

Prediction of postoperative health-related quality of life among patients with metastatic spinal cord compression secondary to lung cancer

Fu,

Shi,

Zhao

et al. 2023

Front. Endocrinol.

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“…BMI, sex and age have also been used, together with other socio-economic, lifestyle and treatment-related factors, to predict quality of life in colorectal cancer survivors long after the diagnosis (~5-6 years after the initial diagnosis) (41).…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life in patients with advanced colorectal cancer: a predictive nomogram including BMI, sex and age

Formica¹,

Nardecchia²,

Morelli³

et al. 2021

Ann Palliat Med

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Background: Health-related quality of life (HRQoL) is not universally assessed in metastatic colorectal cancer (mCRC) patients. We tried to identify patient subgroups for whom HRQoL assessment should be strongly encouraged.Methods: Consecutive mCRC patients who had been deemed candidates for first-line chemotherapy were enrolled in a prospective study (NCT03873064) and asked to complete the HRQoL questionnaire EORTC QLQ-C30. Primary endpoint was the Global Health Status (GHS) of EORTC QLQ-C30. A nomogram was built for prediction of low GHS (i.e., <67%).Results: Among recruited patients (n=173), a univariable logistic regression analysis (LRA) found that body mass index (BMI <23), age (>65 years) and sex (female) were significantly associated with low GHS. The multivariable LRA confirmed they were independently associated with the outcome (P values of 0.04-0.004). BMI, age and sex were included in a final predictive model (C-statistics, 67%; P=0.001) and used to build a nomogram. A total nomogram score ≥72 was associated with a risk of 28% or higher of having a low GHS.The 28% risk cut-off had a sensitivity of 90% and a specificity of 34% for identifying low GHS. A decision curve analysis revealed that a risk threshold of 28% of the model was associated to an added net benefit of ≥4% when using the nomogram. Low GHS was recorded in 58% vs. 23% of patients with >28% vs. <28% risk according to the nomogram, respectively (odds ratio 3.54, P=0.0004). Conclusions:High BMI together with young age and male sex were protective against HRQoL deterioration. In centers where HRQoL is not routinely assessed, such an assessment should be at least made for mCRC patients at risk according to the proposed nomogram (i.e., over 65-year-old females with BMI <23).

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“…The validity of the FFQ for measuring dietary intake among survivors of CRC within the EnCoRe study appeared to be moderate to good for most nutrients and food groups, relative to a 7-day dietary record 91. Prediction models were developed for estimating 1-year risk of low health-related quality of life in seven domains in CRC survivors and performed well when externally validated among survivors within the EnCoRe and COLON studies 92…”

Section: Introductionmentioning

confidence: 99%

“… 91 Prediction models were developed for estimating 1-year risk of low health-related quality of life in seven domains in CRC survivors and performed well when externally validated among survivors within the EnCoRe and COLON studies. 92 …”

Section: Introductionmentioning

confidence: 99%

Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival – the FOCUS Consortium

et al. 2022

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PurposeThe overarching goal of the FOCUS (biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer (CRC) recurrence and survival) Consortium is to unravel the effect of folate and folate-mediated one-carbon metabolism (FOCM) biomarkers on CRC prognosis to provide clinically relevant advice on folate intake to cancer patients and define future tertiary prevention strategies.ParticipantsThe FOCUS Consortium is an international, prospective cohort of 2401 women and men above 18 years of age who were diagnosed with a primary invasive non-metastatic (stages I–III) CRC. The consortium comprises patients from Austria, two sites from the Netherlands, Germany and two sites from the USA. Patients are recruited after CRC diagnosis and followed at 6 and 12 months after enrolment. At each time point, sociodemographic data, data on health behaviour and clinical data are collected, blood samples are drawn.Findings to dateAn increased risk of cancer recurrences was observed among patients with higher compared with lower circulating folic acid concentrations. Furthermore, specific folate species within the FOCM pathway were associated with both inflammation and angiogenesis pathways among patients with CRC. In addition, higher vitamin B6status was associated with better quality of life at 6 months post-treatment.Future plansBetter insights into the research on associations between folate and FOCM biomarkers and clinical outcomes in patients with CRC will facilitate the development of guidelines regarding folate intake in order to provide clinically relevant advice to patients with cancer, health professionals involved in patient care, and ultimately further tertiary prevention strategies in the future. The FOCUS Consortium offers an excellent infrastructure for short-term and long-term research projects and for combining additional biomarkers and data resulting from the individual cohorts within the next years, for example, microbiome data, omics and multiomics data or CT-quantified body composition data.

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Development and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains

Cited by 13 publications

References 52 publications

Prediction of postoperative health-related quality of life among patients with metastatic spinal cord compression secondary to lung cancer

Prediction of postoperative health-related quality of life among patients with metastatic spinal cord compression secondary to lung cancer

Health-related quality of life in patients with advanced colorectal cancer: a predictive nomogram including BMI, sex and age

Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival – the FOCUS Consortium

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