Development and integration of an extended embryo culture program

Patton, Phillip E.; Sadler-Fredd, Karen; Burry, Kenneth A.; Gorrill, Marsha J.; Johnson, Aron; Larson, Jason; Wolf, Don P.

doi:10.1016/s0015-0282(99)00294-0

Cited by 23 publications

(8 citation statements)

References 13 publications

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“…Patton et al 14, and Zollner et al (15) in cohort retrospective studies found blastulation rates from 26 to 48% with ICSI compared to 41 to 57% with IVF. Nevertheless, the pregnancy and implantation rates with BT were similar with conventional IVF and ICSI in these studies (3,12,13,15).…”

Section: Discussionsupporting

confidence: 59%

“…A perhaps more relevant way of assessing whether blastocyst culture is detrimental in ICSI cycles is to compare day 5 to day 3 embryo transfer results. Patton et al (3) found similar pregnancy rates in ICSI cycles (43% with day 5 and 21% with day 3), but the implantation rate was significantly higher with day 5 (36%) compared to day 3 (11%). Coskun et al (12), in a prospective randomized study, found equal pregnancy rates (44% with day 5 and 45% with day 3) and implantation rates (24% with day 5 and 27% with day 3).…”

Section: Discussionmentioning

confidence: 90%

“…2 Stanford University School of Medicine, 300 Pasteur Drive, HH333, Stanford, California 94035. 3 To whom correspondence should be addressed; e-mail: lynnw@stanford.edu.…”

Section: Introductionmentioning

confidence: 99%

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Westphal

Hinckley

Behr

et al. 2003

Journal of Assisted Reproduction and Genetics

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 90%

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Untitled

Westphal

Hinckley

Behr

et al. 2003

Journal of Assisted Reproduction and Genetics

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“…13 What is evident from such works is that culture media are now available that can support high levels of human blastocyst development, which can subsequently implant at very high rates (around 50% 32 ). In the case of oocyte donors, which represent an excellent source of high-quality oocytes, blastocyst rates of 60% can be routinely obtained [34][35][36] with concomitant implantation rates (fetal heartbeat) of 65%. 35 Such an implantation rate is significantly higher than that obtained for oocyte donors having an embryo transfer on day 3 in the same program (41.6%).…”

Section: The Laboratory As An Environment For the Precompacted Embryomentioning

confidence: 99%

Blastocyst Versus Day 2 or 3 Transfer

Schoolcraft¹

2001

Semin Reprod Med

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The formulation of new sequential culture media, capable of supporting the development of viable human blastocysts, has reopened the discussion regarding the best day for embryo transfer following in vitro fertilization (IVF). Although several laboratories have reported overall increases in implantation rate and IVF efficiency following the transfer of blastocysts, others have failed to observe any benefit from extended culture. While culture conditions for the mammalian embryo undoubtedly have improved significantly over the past few years, relatively little attention has been paid to the quality of oocytes derived from ovarian hyperstimulation or the quality and receptivity of the endometrium following such hormonal regimes. It appears that differences in controlled ovarian hyperstimulation are among the major factors determining embryo quality and subsequent implantation. This therefore has confounded comparisons between different laboratories. In spite of this there are a growing number of reports demonstrating that the advantages of extended culture and blastocyst transfer, such as increased implantation rates, are not limited to specific groups of patients or specific etiologies. Rather, blastocyst transfer may be of benefit to the majority if not all patients attending for IVF.

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“…With the ability to select the most developmentally capable embryos, the number of embryos transferred per cycle could potentially be reduced, thereby limiting high-order multiple pregnancies while maintaining an acceptable pregnancy rate (PR). Day 5 ETs at the blastocyst stage were extensively studied; they maintain certain advantages and risks when compared to transfers on day 3 (8,9). Advantages include a better selection of embryos and acceptable success rates, with the transfer of fewer embryos.…”

mentioning

confidence: 99%