Development and in-vitro evaluation of chitosan chloride decorated PLGA based polymeric nanoparticles of nimesulide

Sengel-Türk, Ceyda Tuba; Bayram, Bilge

doi:10.29228/jrp.28

Cited by 2 publications

(1 citation statement)

References 26 publications

(34 reference statements)

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“…Unlike the emulsion diffusion method, the organic solvent cannot diffuse because of the presence of salts. However, the ionic strength is reduced by the dilution of the o/w emulsion with water, under mild stirring, which leads to the migration of the solvent to the outer aqueous phase and the formation of the PLGA NPs [ 37 , 38 , 39 ]. Finally, the salting out agent is removed by cross-flow filtration or centrifugation.…”

Section: Preparation Of Plga Npsmentioning

confidence: 99%

Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines

El-Hammadi

Arias

2022

Nanomaterials

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Therapeutics are habitually characterized by short plasma half-lives and little affinity for targeted cells. To overcome these challenges, nanoparticulate systems have entered into the disease arena. Poly(d,l-lactide-co-glycolide) (PLGA) is one of the most relevant biocompatible materials to construct drug nanocarriers. Understanding the physical chemistry of this copolymer and current knowledge of its biological fate will help in engineering efficient PLGA-based nanomedicines. Surface modification of the nanoparticle structure has been proposed as a required functionalization to optimize the performance in biological systems and to localize the PLGA colloid into the site of action. In this review, a background is provided on the properties and biodegradation of the copolymer. Methods to formulate PLGA nanoparticles, as well as their in vitro performance and in vivo fate, are briefly discussed. In addition, a special focus is placed on the analysis of current research in the use of surface modification strategies to engineer PLGA nanoparticles, i.e., PEGylation and the use of PEG alternatives, surfactants and lipids to improve in vitro and in vivo stability and to create hydrophilic shells or stealth protection for the nanoparticle. Finally, an update on the use of ligands to decorate the surface of PLGA nanomedicines is included in the review.

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Section: Preparation Of Plga Npsmentioning

confidence: 99%

Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines

El-Hammadi

Arias

2022

Nanomaterials

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Research Progress on Immunomodulatory Effects of Poly (Lactic-co- Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers

Song,

Chen,

Tong

et al. 2024

CDD

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Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance of the environment in humans. When the immune function of the immune system is impaired, autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition, genetic factors and other reasons cause low immune function, due to which the body is prone to being infected by bacteria or cancer. Clinically, the existing therapeutic drugs still have problems such as high toxicity, long treatment cycle, drug resistance and high price, so we still need to explore and develop a high efficiency and low toxicity drug. Poly(lactic-co-glycolic acid) (PLGA) refers to a non-toxic polymer compound that exhibits excellent biocompatibility. Traditional Chinese medicine (TCM) monomers come from natural plants, and have the characteristics of high efficiency and low toxicity. Applying PLGA to TCM monomers can make up for the defects of traditional dosage forms, improve bioavailability, reduce the frequency and dosage of drug use, and reduce toxicity and side effects, thus having the characteristics of sustained release and targeting. Accordingly, PLGA nano-particles loaded with TCM monomers have been the focus of development. The previous research on drug loading advantages, preparation methods, and immune regulation of TCM PLGA nanoparticles is summarized in the following sections.

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Development and in-vitro evaluation of chitosan chloride decorated PLGA based polymeric nanoparticles of nimesulide

Abstract: How to cite this article: Sengel-Turk CT, Bayram B. Development and in-vitro evaluation of chitosan chloride decorated PLGA based polymeric nanoparticles of nimesulide.

Cited by 2 publications

References 26 publications

Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines

Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines

Research Progress on Immunomodulatory Effects of Poly (Lactic-co- Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers

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