Development and in vitro evaluation of a novel floating multiple unit dosage form obtained by melt pelletization

Hamdani, Jamila; Moes, André Jules; Amighi, Karim

doi:10.1016/j.ijpharm.2006.05.052

Cited by 37 publications

(13 citation statements)

References 19 publications

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“…Drug loaded porous calcium silicate microspheres coated with Eudragit ® S also exhibited floating and controlled release (Jain et al, 2005). Multi-step processing and the need for organic solvents is a common feature of the above methods (Hamdani et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion

Malode

Paradkar

Devarajan

2015

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion

Malode

Paradkar

Devarajan

2015

International Journal of Pharmaceutics

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“…Lipid-based excipients such as triglycerides and fatty acids have been used for the development of solid dosage forms as matrices for controlled drug release [7][8][9][10], as tastemasking agents [11], to enhance drug solubility [12][13][14] and for the manufacturing of floating dosage forms [15,16]. Compared to polymers [17], triglycerides exhibit several advantages, including low cost, non-toxicity and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Vervaeck

Saerens

Geest

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

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“…At equilibrium of floating pellets, the magnitude and direction of the force, F net , corresponded to the vectorial sum of the buoyancy ( F buoy ) and gravitational ( F grav ) forces acting on the pellet [28]. By definition, the more positive F net is (forces directed upward), the faster and longer a pellet floats.…”

Section: Methodsmentioning

confidence: 99%

Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics

et al. 2014

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Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young’s modulus, and toughness) of these plasticized polymeric films of acrylic (Eudragit RS, RL, and NE) and cellulosic materials (ethyl cellulose (EC), and Surelease) were examined by a dynamic mechanical analyzer. Results demonstrated that polymeric films prepared from Surelease and EC were brittle with less elongation compared to acrylic films. Eudragit NE films were very flexible in both the dry and wet states. Because plasticizer leached from polymeric films during exposure to the aqueous medium, plasticization of wet Eudragit RS and RL films with 15% triethyl citrate (TEC) or diethyl phthalate (DEP) resulted in less elongation. DEP might be the plasticizer of choice among the plasticizers examined in this study for Eudragit RL to provide muFDDSs with a short time for all pellets to float (TPF) and a longer period of floating. Eudragit RL and RS at a 1∶1 ratio plasticized with 15% DEP were optimally selected as the coating membrane for the floating system. Although the release of losartan from the pellets was still too fast as a result of losartan being freely soluble in water, muFDDSs coated with Eudragit RL and RS at a 1∶1 ratio might have potential use for the sustained release of water-insoluble or the un-ionized form of drugs from gastroretentive drug delivery systems.

show abstract

Development and in vitro evaluation of a novel floating multiple unit dosage form obtained by melt pelletization

Cited by 37 publications

References 19 publications

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics

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