Development and in vitro characterization of microemulsions of isotretinoin

Gürbüz, Aslı; Güngör, Sevgi; Erdal, Meryem Sedef

doi:10.23893/1307-2080.aps.0559

Cited by 1 publication

(2 citation statements)

References 36 publications

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“…. 8:2; 9:1] [291]. Novel approaches of Wani et al showed the possibility to prepare O/W microemulsions with isotretinoin which can be administered by spraying.…”

Section: Application Of Microemulsions For Anti-acne Drug Deliverymentioning

confidence: 99%

“…The study was projected as a screening, analyzing the impact of various CoSs on the formulation process, as can be observed in Table 4 . Six groups of MEs were formulated using Labrasol as a surfactant, combined with Kolliphor EL or Kolliphor HS or Plurol oleique as a CoS. IPM was added, keeping the ratios of Oil:S/CoS in the interval [1:9; 2:8…8:2; 9:1] [ 291 ]. Novel approaches of Wani et al showed the possibility to prepare O/W microemulsions with isotretinoin which can be administered by spraying.…”

Section: Microemulsions In a New Vision For An Optimized Acne Thermentioning

confidence: 99%

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Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

et al. 2020

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With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.

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“…. 8:2; 9:1] [291]. Novel approaches of Wani et al showed the possibility to prepare O/W microemulsions with isotretinoin which can be administered by spraying.…”

Section: Application Of Microemulsions For Anti-acne Drug Deliverymentioning

confidence: 99%

Section: Microemulsions In a New Vision For An Optimized Acne Thermentioning

confidence: 99%

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

et al. 2020

View full text Add to dashboard Cite

show abstract

Development and in vitro characterization of microemulsions of isotretinoin

Cited by 1 publication

References 36 publications

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

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