Development and Implementation of a Multidisciplinary Sepsis Protocol

Temporal changes in physiological parameters of systemic inflammatory response syndrome during the three days prior to a diagnosis of sepsis: a case–control study

“…, Picard et al . , Neviere ), we computed SIRS criteria scores, that is, we awarded each of the following one point: temperature >38 °C or <36 °C, heart rate > 90/min, respiratory rate > 20/min, PaCO 2 < 32 mmHg and white blood cell count > 12,000 cell/mm 3 or <4000 cell/mm 2 . In the present study, those at high risk of SIRS were defined as having a SIRS score of ≥2 (Bochicchio et al .…”

“…As defined by the American College of Chest Physicians (ACCP) and Society of Critical Medicine (SCCM) Consensus Conference in 1992, severe sepsis is associated with the presence of organ dysfunction, hypoperfusion, or hypotension, whereas septic shock is sepsis with hypotension despite adequate fluid replacement combined with clinical signs of perfusion abnormalities, such as lactic acidosis, oliguria and altered mental status (American College of Chest Physicians‐Society of Critical Medicine , Picard et al . ).…”

“…Systemic inflammatory response syndrome frequently occurs among critically ill patients in intensive care units (ICUs) or emergency departments (Picard et al . , Comstedt et al . ), and is triggered by a variety of causes, of either an infectious or noninfectious nature.…”

“…), (2) conceptual definition and attributes (Picard et al . , Lever & Mackenzie , Dodge ), (3) clinical manifestations (Picard et al . , Dodge ), and (4) the development of therapeutic guidelines (Picard et al .…”

“…, Lever & Mackenzie , Dodge ), (3) clinical manifestations (Picard et al . , Dodge ), and (4) the development of therapeutic guidelines (Picard et al . , Shapiro et al .…”