Development and Implementation of a U-500 Regular Insulin Program in a Federally Qualified Health Center

Shaw, Kathy; Valdez, Connie

doi:10.2337/cd16-0057

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…This syringe has been widely preferred since it lowers the risk of intramuscular injections [21]. In 2016, the FDA approved a U-500 specific insulin syringe designed by BD to address the dosing errors while administering doses from a U-500 vial with a U-100 insulin syringe [22]. In place of the long, large bore-sized and reusable needles used in earlier years, currently, small bore-sized and short-length needles (8 mm, 6 mm, and 5 mm) are used for insulin injection.…”

Section: Insulin Syringesmentioning

confidence: 99%

“…Despite all the above-mentioned advances, most patients experienced difficulty in injecting insulin multiple times a day [16]. Besides, the use of syringes was associated with poor dose accuracy, a long training period, unpleasant psychologic impact, and difficulties in conveyance [11,22,23]. These negative impacts led to a lack of treatment persistence and nonadherence and created barriers to achieving glycemic control [24].…”

Section: Limitationsmentioning

confidence: 99%

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Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas

Saboo²,

et al. 2020

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The year 2021 will mark 100 years since the discovery of insulin. Insulin, the first medication to be discovered for diabetes, is still the safest and most potent glucose-lowering therapy. The major challenge of insulin despite its efficacy has been the occurrence of hypoglycemia, which has resulted in sub-optimal dosages being prescribed in the vast majority of patients. Popular devices used for insulin administration are syringes, pens, and pumps. An artificial pancreas (AP) with a closed-loop delivery system with [ 95% time in range is believed to soon become a reality. The development of closed-loop delivery systems has gained momentum with recent advances in continuous glucose monitoring (CGM) and computer algorithms. This review discusses the evolution of syringes, disposable, durable pens and connected pens, needles, tethered and patch insulin pumps, bionic pancreas, alternate controller-enabled infusion (ACE) pumps, and do-it-yourself artificial pancreas systems (DIY-APS).

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Section: Insulin Syringesmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas

Saboo²,

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Becton Dickinson had discovered the primarily specified syringe in 1924 [143]. After that, many advances in this syringe were made to improve the delivery system such as novo syringe [144], plastic syringes [145], U-100 plastic syringe [145], U-500 insulin syringe [146], etc. Despite all these advances in syringes, patients felt inconvenience in subjecting insulin multiple times in a day.…”

Section: Some Obstacles Faced By Patients With Diabetes Through Insul...mentioning

confidence: 99%

Proteomic Changes to the Updated Discovery of Engineered Insulin and Its Analogs: Pros and Cons

Hanif

Wu²,

et al. 2022

CIMB

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The destruction of β-cells of the pancreas leads to either insulin shortage or the complete absence of insulin, which in turn causes diabetes Mellitus. For treating diabetes, many trials have been conducted since the 19th century until now. In ancient times, insulin from an animal’s extract was taken to treat human beings. However, this resulted in some serious allergic reactions. Therefore, scientists and researchers have tried their best to find alternative ways for managing diabetes with progressive advancements in biotechnology. However, a lot of research trials have been conducted, and they discovered more progressed strategies and approaches to treat type I and II diabetes with satisfaction. Still, investigators are finding more appropriate ways to treat diabetes accurately. They formulated insulin analogs that mimic the naturally produced human insulin through recombinant DNA technology and devised many methods for appropriate delivery of insulin. This review will address the following questions: What is insulin preparation? How were these devised and what are the impacts (both positive and negative) of such insulin analogs against TIDM (type-I diabetes mellitus) and TIIDM (type-II diabetes mellitus)? This review article will also demonstrate approaches for the delivery of insulin analogs into the human body and some future directions for further improvement of insulin treatment.

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Insulin Delivery: An Evolution in the Technology

Kesavadev,

Krishnan,

Benny

2023

The Diabetes Textbook

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Development and Implementation of a U-500 Regular Insulin Program in a Federally Qualified Health Center

Cited by 3 publications

References 10 publications

Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas

Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas

Proteomic Changes to the Updated Discovery of Engineered Insulin and Its Analogs: Pros and Cons

Insulin Delivery: An Evolution in the Technology

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