2012
DOI: 10.1016/j.semcdb.2012.08.010
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Development and homeostasis of the sebaceous gland

Abstract: The important role of epidermal appendages especially the sebaceous gland has only recently been recognised. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signalling network controlling proper sebaceous lineage … Show more

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Cited by 120 publications
(122 citation statements)
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“…Cell transplantation and lineage tracing studies revealed that the SG is fuelled by multiple stem cell populations (22,23). Committed cells entering the SG initially locate at the gland periphery and proliferate for some time, before accumulating large amounts of lipids to finally disintegrate and release their content via holocrine secretion (24,25).…”
Section: Discussionmentioning
confidence: 99%
“…Cell transplantation and lineage tracing studies revealed that the SG is fuelled by multiple stem cell populations (22,23). Committed cells entering the SG initially locate at the gland periphery and proliferate for some time, before accumulating large amounts of lipids to finally disintegrate and release their content via holocrine secretion (24,25).…”
Section: Discussionmentioning
confidence: 99%
“…In turn, p63 expression in epidermal keratinocytes is regulated by miR-203, miR-720, and miR-574-3p, which are expressed in cells within the suprabasal epidermal layer and restrict p63 expression to basal cells (Yi et al 2008;Chikh et al 2011). In addition to the hair bulb, epidermal progenitors generate the sebaceous gland, which secretes sebum via the duct penetrating the upper part of the follicular epithelium and extrudes it into the hair follicle infundibulum (Niemann and Horsley 2012). Postnatally, the hair follicle undergoes cyclic transformations with periods of active growth (anagen), involution (catagen), and resting (telogen) (Stenn and Paus 2001).…”
Section: Va Botchkarev and Er Floresmentioning
confidence: 99%
“…Biosynthesis of cholesterol and other lipids in the skin is essential for the formation of the epidermal permeability barrier, for hair follicle morphogenesis, and for hair follicle maintenance (2)(3)(4)(5)(6)(7)(8). Sebaceous glands and epidermal keratinocytes are the two major sources of skin lipid production (9). Sebocytes are terminally differentiated epithelial cells of sebaceous glands that produce and secrete sebum, a lipid mixture composed of triglycerides and fatty acids (57.5%), wax esters (26%), squalene (12%), and cholesterol (4.5%) (10).…”
mentioning
confidence: 99%