Development and Heterogeneity of Prolactin Cells

Takahashi, Sumio

doi:10.1016/s0074-7696(08)62156-7

Cited by 31 publications

(23 citation statements)

References 355 publications

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“…Transdifferentiation of GH cells into PRL cells had been previously suggested in several reports (Hoeffler et al ., 1985;Frawley and Boockfor, 1991;Takahashi, 1995). Initial differentiation of PRL cells from GH cells is a post-mitotic process in the immature mouse pituitary gland (Behringer et al ., 1988;Borrelli et al ., 1989).…”

Section: Discussionmentioning

confidence: 99%

“…We have recently demonstrated that PRL cells differentiate from GH cells through mammosomatotrophs (MS cells), which synthesize and secrete both GH and PRL in response to a combined treatment of epidermal growth factor (EGF), insulin and estradiol-17 β (E 2 ) in rat pituitary tumor GH3 cells . In contrast, the proliferation of PRL cells is a well-known event in the rat and mouse pituitary gland (Takahashi, 1995). The highest mitotic activity of PRL cells is observed at estrus in the female rat pituitary (Takahashi et al ., 1984;Oishi et al ., 1993).…”

Section: Introductionmentioning

confidence: 99%

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Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17β in rat pituitary tumor GH3 cells

Kakeya

Tanaka

Takahashi³

2002

Zoological Science

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-Several reports have indicated that prolactin-secreting cells (PRL cells) are generated from growth hormone-secreting cells (GH cells). We have shown that treatment with a combination of epidermal growth factor (EGF), insulin, and estradiol-17 β (E 2 ) induces the appearance of PRL cells in pituitary tumor GH3 cells. The aim of the present study was to clarify the involvement of mitosis in the cytogenesis of PRL cells in rat pituitary and GH3 cells. The effects of the treatment with EGF, insulin and E 2 on DNAreplication were studied by detecting the uptake of bromodeoxyuridine (BrdU) into the nucleus. In cultured rat pituitary cells, BrdU-labeled PRL cells were observed irrespective of the hormone treatment. In GH3 cells, BrdU-labeled GH cells and mammosomatotrophs (MS cells) were detected; BrdU-labeled PRL cells were not detected, however, when GH3 cells were treated with BrdU for 3 hr and then immediately examined for BrdU-labeling. BrdU-labeled PRL cells were found only when GH3 cells treated with BrdU were allowed to grow for another 3 days. This finding suggests that during the additional 3-day culture, BrdUlabeled PRL cells were generated from BrdU-labeled cells other than PRL cells. These results indicate that PRL cells are transdifferentiated from GH cells or MS cells in GH3 cells by a combined treatment with EGF, insulin and E 2 , while PRL cells in rat pituitaries are able to proliferate in response to the hormone treatment. Thus, there may be two pathways for cytogenesis of PRL cells: the transdifferentiation of GH cells or MS cells, and a self-duplication of PRL cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17β in rat pituitary tumor GH3 cells

Kakeya

Tanaka

Takahashi³

2002

Zoological Science

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“…Much evidence has shown that differentiation and growth of secretory cells and regulation of hormone secretion are partly regulated by growth factors and cytokines produced in the pituitary gland, and also by hormones produced in the hypothalamus and peripheral endocrine organs (Schwartz & Cherny 1992, Takahashi 1995, Renner et al 1996, Ray & Melmed 1997. Growth of mammotrophs is partly regulated by ovarian oestrogen and hypothalamic dopamine (Lloyd et al 1975, Takahashi & Kawashima 1987.…”

Section: Introductionmentioning

confidence: 99%

Transforming growth factor-alpha stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary

Oomizu

Honda

Tanaka

et al. 2000

Journal of Endocrinology

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Oestrogen stimulates the proliferation of pituitary cells. The present study was designed to clarify the involvement of transforming growth factor-(TGF-) in the oestrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR male mice were cultured in a primary serum-free culture system. Proliferation of pituitary cells was detected by monitoring the cellular uptake of bromodeoxyuridine. Secretory cell types were immunocytochemically determined. Treatment with TGF-(0·1 and 1 ng/ml) for 5 days stimulated cell proliferation. Since TGF-binds to the epidermal growth factor (EGF) receptor, this action may be exerted through the EGF receptor.

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“…Mammotrophs are the most actively proliferating cells in rat and mouse pituitaries (Shirasawa and Yoshimura, 1982;Takahashi and Kawashima, 1982;Takahashi, 1992;Takahashi, 1995). In adult female rats the mitotic activity of mammotrophs is higher during estrus than during any other stage of the estrous cycle (Takahashi et al , 1984;Oishi et al , 1993).…”

Section: Mammotroph Proliferationmentioning

confidence: 99%

“…Secretory cell numbers are determined by the balance between the proliferation and apoptosis of pituitary secretory cells, which is partly regulated by growth factors and cytokines produced in the pituitary gland as well as hypothalamic hormones and hormones from the target organs (Schwartz and Cherny, 1992;Denef, 1994;Takahashi, 1995;Renner et al , 1996;Ray and Melmed, 1997;Schwartz, 2000). This review describes the actions of growth factors produced within the pituitary gland and shows the intrapituitary regulatory system involved in controlling pituitary functions.…”

Section: Introductionmentioning

confidence: 99%

Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland

Takahashi

2004

Zoological Science

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-Anterior pituitary cells produce growth factors plus cytokines and their receptors. Although some of these pituitary growth factors and cytokines are known to be involved in the control of cell differentiation, proliferation and hormone production in the pituitary gland, their physiological roles remain unknown. Lots of evidence indicates that they are involved in the regulation of prolactin-secreting mammotroph cell proliferation. The regulation of mammotroph functions is a suitable system for understanding the intrapituitary regulatory system operated by growth factors and cytokines, since mammotrophs are the most actively proliferating cells in female pituitary glands. This review discusses the possible intrapituitary regulation of mammotroph differentiation and proliferation in rat and mouse pituitaries.

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Development and Heterogeneity of Prolactin Cells

Cited by 31 publications

References 355 publications

Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17β in rat pituitary tumor GH3 cells

Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17β in rat pituitary tumor GH3 cells

Transforming growth factor-alpha stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary

Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland

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