Development and function of the thymus in teleosts

Bowden, Timothy J.; Cook, Peter C.; Rombout, J.H.W.M.

doi:10.1016/j.fsi.2005.02.003

Cited by 114 publications

(106 citation statements)

References 85 publications

(117 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The thymus is located in the dorsolateral part of the gill chamber and originates from the second to fourth of the pharyngeal pouches (7). Interestingly, the corresponding region also gives rise to the Waldeyer's ring of secondary lymphoid structures as found in humans (8).…”

mentioning

confidence: 99%

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Bergva

Austbø

König

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

Previously, our group has shown that the interbranchial lymphoid tissue (ILT) is a distinct structure largely consisting of T cells embedded in a meshwork of epithelial cells, with no direct resemblance to previously described lymphoid tissues. In this study, we aim to focus on the T cell population and the possibility of the ILT being a thymus analog. By characterizing structural responsiveness to Ag challenge, the presence of recombination activating genes, and different T cell–related transcripts, we attempt to further approach the immunological function of the ILT in salmonid gills. In addition to eight healthy individuals, a group of eight infectious salmon anemia virus–challenged fish were included to observe T cell responses related to infection. The results showed reduced size of ILT in the infected group, no expression of RAG-1 and -2, and a high degree of T cell diversity within the ILT. Taking into account that the ILT can be regarded as a strategically located T cell reservoir and possibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, the alteration in transcription observed may likely represent a shift in the T cell population to optimize local gill defense mechanisms.

show abstract

mentioning

confidence: 99%

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Bergva

Austbø

König

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…They were described in lungfish (Mohammad et al 2007), in teleosts (Bowden et al 2005) and in mammals (Furukawa et al 2012).…”

Section: Discussionmentioning

confidence: 99%

The first finding of Hassall's corpuscles in the thymi of cultured sturgeons

Šálková¹,

Flajšhans²

2016

Vet. Med. - Czech

View full text Add to dashboard Cite

Histological examination of thymi from juvenile Acipenser ruthenus and Acipenser brevirostrum after haematoxylin and eosin staining revealed the presence of Hassall's corpuscles, in a scattered distribution within the thymic medulla in two of seven, and one of nine examined specimens, respectively. Morphologically, the Hassall's corpuscles were of the juvenile and premature type and no degenerative changes were seen.

show abstract

“…It is a crossroad between the immune and the neuroendocrine systems 1 . From phylogenetical point of view, thymus played a key role in the evolution of animals during development of adaptive immune system; therefore it is an important feature separating higher vertebrates from other animals 2,3 . The thymus plays an important role in providing a suitable microenvironment for the proliferation, differentiation and selection of T lymphocytes that are responsible for cellular imunity [3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Association Among Size of Thymus, Anthropometric Dimensions and Number of Lymphocytes in Peripheral Blood in Newborns From Slovakia

Varga¹,

Toth²,

Uhrinova³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Aims:Thymus is the central lymphatic organ in humans with important endocrine function that is involved in maturation of immunocompetent T-lymphocytes. In our study we investigated the relationship among thymus size and the anthropometric dimensions as well as between thymus size and the number of lymphocytes in peripheral blood in full-term newborns.Methods: The examined group consisted of 212 full-term newborns from the region of Southern Slovakia. We examined birth weight, birth body length, head circumference and chest circumference. Thymus size was estimated by ultrasonography and it was expressed as Thymic Index. The number of lymphocytes in peripheral blood was determined from the number of total leukocytes and from the leukogram.Results: We have found a statistically significant positive correlation among thymus size and the body dimensions of newborns. The highest correlation with thymus size was found for birth weight (r = 0.409; P < 0.001) followed by birth body length (r = 0.368; P < 0.001), head circumference (r = 0.365; P < 0.001) and chest circumference (r = 0.340; P < 0.001). We have proven also a statistically significant positive correlation between the number of lymphocytes in peripheral blood and thymus size (r = 0.208; P = 0.039).Conclusion: Our results confirmed the findings of other authors about a close relationship of Thymic Index and basic body parameters in newborns.

show abstract

Development and function of the thymus in teleosts

Cited by 114 publications

References 85 publications

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue

The first finding of Hassall's corpuscles in the thymi of cultured sturgeons

Association Among Size of Thymus, Anthropometric Dimensions and Number of Lymphocytes in Peripheral Blood in Newborns From Slovakia

Contact Info

Product

Resources

About