Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors

Schenk, Susan; Valadez, Albert A.; McNamara, C.; House, David T.; Higley, Dean; Bankson, Michael G.; Gibbs, Sharon L.; Horger, Brian A.

doi:10.1007/bf02244949

Cited by 123 publications

(67 citation statements)

References 37 publications

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“…Also, cocaine CPP can be induced with lower cocaine doses or fewer conditioning trials in rats that receive repeated experimenter-administered injections of cocaine prior to the start conditioning (Shippenberg and Heidbreder, 1995). A similar phenomenon has been demonstrated with the selfadministration procedure (e.g., Schenk et al, 1993;Schenk and Partridge, 2000), and these data have been used to support the argument that pre-exposure to cocaine produces sensitization to the reinforcing effects of the drug. Our identification of a subgroup of rats that are more likely to develop both sensitization and CPP complements these findings and establishes a methodology with which to investigate genetic and other individual neurobiological differences that contribute to learning in the context of cocaine reward.…”

Section: Discussioncontrasting

confidence: 39%

Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Allen

Everett²,

Nelson³

et al. 2007

Pharmacology Biochemistry and Behavior

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Outbred, male Sprague-Dawley rats can be classified as either low or high cocaine responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an open-field arena. This difference reflects cocaine's ability to inhibit the striatal dopamine transporter and predicts development of sensitization. To investigate the relationship between initial cocaine locomotor responsiveness and cocaine reward, here we first classified rats as either LCRs or HCRs in a conditioned place preference (CPP) apparatus. Subsequently, we conducted cocaine conditioning trials, twice daily over four days with vehicle and cocaine (10 mg/kg, i.p. or 1 mg/kg, i.v.). When cocaine was administered by the i.p. route, similar to previous findings in the open-field, LCRs and HCRs were readily classified and locomotor sensitization developed in LCRs, but not HCRs. However, cocaine CPP was not observed. In contrast, when cocaine was administered by the i.v. route, the LCR/HCR classification not only predicted sensitization, but also CPP, with only LCR rats exhibiting sensitization and cocaine conditioning. Our findings show that the initial locomotor response to cocaine can predict CPP in male Sprague-Dawley rats under conditions when place conditioning develops, and that LCRs may be more prone to develop conditioning in the context of cocaine reward.

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Section: Discussioncontrasting

confidence: 39%

Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Allen

Everett²,

Nelson³

et al. 2007

Pharmacology Biochemistry and Behavior

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“…Glutamate receptor antagonists, as well as excitotoxic lesions of the prefrontal cortex (PFC), can block the development of behavioral sensitization to psychostimulants (Karler et al, 1989(Karler et al, , 1994Wolf and Khansa, 1991;Kalivas and Alesdatter, 1993;Schenk et al, 1993;Stewart and Druhan, 1993;Wolf and Jeziorski, 1993;Ohmori et al, 1994;Wolf et al, 1995;Cador et al, 1999). Moreover, release of glutamate in the NAc and VTA is enhanced in amphetamine-sensitized rats (Xue et al, 1996;Wolf andXue, 1998, 1999;Wolf et al, 2000).…”

Section: Introductionsupporting

confidence: 41%

Expression of Amphetamine-Induced Behavioral Sensitization after Short- and Long-Term Withdrawal Periods: Participation of μ- and δ-Opioid Receptors

Magendzo

Bustos

2002

Neuropsychopharmacol

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Repeated amphetamine administration results in behavioral sensitization, an enduring behavioral transformation expressed after short and long periods of withdrawal. To investigate the participation of the opioid system in amphetamine-induced behavioral sensitization, we studied the effect of naloxone, an opioid receptor antagonist, on the expression of behavioral sensitization tested after short-(2 days) and long-term (14 days) withdrawal periods. In addition, using quantitative competitive RT-PCR, we examined the levels of m-opioid receptor (MOR) and d-opioid receptor (DOR) mRNA in the nucleus accumbens shell (NAcSh) and ventral tegmental area (VTA) of behaviorally sensitized rats, at these two withdrawal times. This study showed that whereas naloxone did not modify the expression of behavioral sensitization tested after 2 days of withdrawal, it completely blocked the expression when tested after 14 days of withdrawal. DOR and MOR mRNA levels were not modified in the NAcSh of rats expressing behavioral sensitization after 2 or 14 days of withdrawal. Conversely, DOR and MOR mRNA levels were elevated in the VTA of animals expressing behavioral sensitization after 2 days of withdrawal. However, whereas DOR mRNA returned to control levels, MOR mRNA levels remained elevated in animals expressing behavioral sensitization after 14 days of withdrawal. These results indicate a striking difference between the role played by opioid receptors in the expression of amphetamine-induced behavioral sensitization, when tested after short-or long-term withdrawal periods. In addition, our results support the notion that repeated amphetamine-induced changes in opioid receptor expression may contribute to the perpetuation of psychostimulant abuse and/or relapse.

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“…There have been recent reports that pretreatment with dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, weakens or prevents the development of adaptations to diverse drugs including CNS stimulants such as amphetamine, methamphetamine and cocaine (Karler et al, 1989;Kuribara et al, 1992;Wolf & Khansa, 1991;Schenk et al, 1993), opioids such as morphine (Trujillo & Akil, 1990;Ben-Eliyahu et al, 1992) and alcohol (Morriset et al, 1990 receptors may play a role in the adaptive responses to nicotine since, when rats are exposed chronically to dizocilpine, as well as to nicotine, the usual sensitization reaction to the locomotor stimulant effect of nicotine fails to develop (Shoaib & Stolerman, 1992b). These data have been interpreted as evidence that activation of NMDA receptors may be a necessary step in the development of sensitization to nicotine.…”

Section: Introductionsupporting

confidence: 41%

Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

Shoaib¹,

Benwell

Akbar³

et al. 1994

British J Pharmacology

111

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1 The repeated co-administration of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (0.1 and 0.3 mg kg-, i.p.) with nicotine (0.4 mg kg-', s.c.) attenuated the development of tolerance to the locomotor depressant effect of the nicotine in rats. 2 The repeated co-administration of the competitive NMDA antagonist D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid, 2 and 8 mg kg-', i.p.) also attenuated tolerance to the locomotor depressant effect of nicotine. 3 Dizocilpine (0.3 mg kg-',i.p.) pretreatment attenuated sensitization to the locomotor stimulant effect of nicotine (0.4 mg kg-', s.c.) and prevented sensitization of nicotine-induced dopamine release in the nucleus accumbens. However, pretreatment with dizocilpine alone caused a modest enhancement of the behavioural response to a subsequent acute dose of nicotine. 4 D-CPPene (2.0 mg kg-', i.p.) pretreatment prevented sensitization to the nicotine-induced dopamine release in the nucleus accumbens. There was no enhanced locomotor response that could be attributed to nicotine pretreatment when D-CPPene was co-administered with nicotine. However, pretreatment with D-CPPene alone enhanced the locomotor response to an acute dose of nicotine. 5 The results suggest the involvement of NMDA receptors in adaptations of the behavioural and neurochemical effects of nicotine that occur as a result of repeated administration of the drug.

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Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors

Cited by 123 publications

References 37 publications

Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Low and high locomotor responsiveness to cocaine predicts intravenous cocaine conditioned place preference in male Sprague–Dawley rats

Expression of Amphetamine-Induced Behavioral Sensitization after Short- and Long-Term Withdrawal Periods: Participation of μ- and δ-Opioid Receptors

Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

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