Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy

Bragagni, Marco; Scozzafava, Andrea; Mastrolorenzo, Antonio; Supuran, Claudiu T.; Mura, Paola

doi:10.1016/j.ijpharm.2015.08.036

Cited by 30 publications

(15 citation statements)

References 42 publications

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“…69 Another study reported that 5-aminolevulinic acid (ALA)-loaded niosomes could significantly increase skin penetration in comparison to simple aqueous suspension. 68 In this study, elastic niosomes were compared with classic niosomes (contains Span 60 and cholesterol) for their potential to improve skin penetration, and the results revealed that although elastic niosomes containing dicethyl-phosphate as edge activator, had lower dimensions, their potential to increase skin penetration and drug deposition was less than classic niosomes, which could be explained by the lower percentage of encapsulation efficiency of elastic niosomes in comparison to classic niosomes. So, conventional niosomes were suggested as suitable nanocarriers for ALA delivery to treat skin malignancies by photodynamic therapy.…”

Section: Niosomesmentioning

confidence: 88%

“…65 The use of ethanol as an organic solvent in niosomes formulation can increase skin penetration through enhancing vesicle elasticity and fluidization of stratum corneum lipids and also by increasing drug solubility and drug partitioning in stratum corneum. 68 The presence of ethanol in niosomes formulation can interact with surfactant molecules and reduce the melting point of the vesicles which could increase their fluidity. Also, ethanol is responsible for the reduction of the mean average diameter of niosomes by surface charge modification and steric stabilization.…”

Section: Niosomesmentioning

confidence: 99%

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<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Ghasemiyeh

Mohammadi-Samani

2020

DDDT

191

113

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The topical route of administration has many advantages for the treatment of various skin disorders as well as cosmeceutical purposes. This route bypasses hepatic firstpass effect and systemic availability of many pharmaceuticals is limited to skin organelles such as hair follicles and so could avoid unwanted adverse reactions and increase the localized therapeutic effect. Despite such attributed advantages of the topical route, the most important challenge is skin barrier characteristics that should be overcome to obtain dermal or trans-dermal drug delivery. Different approaches have been recruited to overcome this barrier. In this review, different types of nanoparticles for skin permeation enhancement and targeted delivery to skin organelles are discussed. The potential mechanisms of each nanocarrier in permeation enhancement and dermal delivery are considered and finally, the most important advantages and disadvantages of each group are summarized.

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Section: Niosomesmentioning

confidence: 88%

Section: Niosomesmentioning

confidence: 99%

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Ghasemiyeh

Mohammadi-Samani

2020

DDDT

191

113

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“…Researchers have also shown that the use of nano-fibers loaded with chlorhexidine and silver nanoparticles leads to heightened antibacterial activity 27 . Photosensitization-based antimicrobials have been under observation for a variety of uses, like topical use for anti-cancer applications 28 . Use of nanoparticle-based delivery systems designed using constituents such as surfactants has been shown to increase the effectiveness of antimicrobial activity 29 .…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Rout

Liu

2017

Sci Rep

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Photosensitization-based antimicrobial therapy (PAT) is an alternative therapy aimed at achieving bacterial inactivation. Researchers use various photosensitizers to achieve bacterial inactivation. However, the most widely used approach involves the use of photosensitizers dispersed in aqueous solution, which could limit the effectiveness of photodynamic inactivation. Therefore, the approaches to encapsulate the photosensitizer in appropriate vehicles can enhance the delivery of the photosensitizer. Herein, Toluidine Blue O (TBO) was the photosensitizer, and lipid nanoparticles were used for its encapsulation. The lipid nanoparticle-based delivery system has been tailor-made for decreasing the average size and viscosity and increasing the formulation stability as well as the wettability of skin. Usage of an appropriate vehicle will also increase the cellular uptake of the photosensitizer into the bacterial cells, leading to the damage on cell membrane and genomic DNA. Evidence of effectiveness of the developed PAT on planktonic bacteria and biofilms was examined by fluorescence microscopy and scanning electron microscopy. Lipid nanoparticles protected the photosensitizer from aggregation and made the application easy on the skin as indicated in data of size distribution and contact angle. The use of lipid nanoparticles for encapsulating TBO could enhance photosensitization-based antimicrobial therapy as compared to the aqueous media for delivering photosensitizers.

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“…ALA-loaded noisome gel was prepared to improve the permeation of the drug across the stratum corneum. Ex vivo skin permeation studies performed on excised human skin showed that the ALA-loaded niosomal formulation showed better penetration across the skin when compared to the aqueous solution of ALA [79]. El-Say et al formulated a diacerein-loaded niosomal gel formulation that exhibited better anti-inflammatory activity compared to the commercial gel formulation.…”

Section: Niosomesmentioning

confidence: 99%

Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

et al. 2020

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The topical route is the most preferred one for administering drugs to eyes, skin and wounds for reaching enhanced efficacy and to improve patient compliance. Topical administration of drugs via conventional dosage forms such as solutions, creams and so forth to the eyes is associated with very low bioavailability (less than 5%) and hence, we cannot rely on these for delivering drugs to eyes more efficiently. An intravitreal injection is another popular drug delivery regime but is associated with complications like intravitreal hemorrhage, retinal detachment, endophthalmitis, and cataracts. The skin has a complex structure that serves as numerous physiological barriers to the entry of exogenous substances. Drug localization is an important aspect of some dermal diseases and requires directed delivery of the active substance to the diseased cells, which is challenging with current approaches. Existing therapies used for wound healing are costly, and they involve long-lasting treatments with 70% chance of recurrence of ulcers. Nanotechnology is a novel and highly potential technology for designing formulations that would improve the efficiency of delivering drugs via the topical route. This review involves a discussion about how nanotechnology-driven drug delivery systems have evolved, and their potential in overcoming the natural barriers for delivering drugs to eyes, skin and wounds.

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Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy

Cited by 30 publications

References 42 publications

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

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