Development and evaluation of taste-masked pediatric minitablet formulations with bitter model drugs

Keser, Stefanie; Timpe, Carsten; Zimmer, Andreas

doi:10.1016/j.ijpharm.2017.08.041

Cited by 2 publications

(2 citation statements)

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“…Microencapsulation creates a physical barrier between the drug and the taste receptors in the form of a polymeric film thus leading to efficient taste masking. Although there are several ways to achieve microencapsulation, fluid bed processing is one of the most efficient, fast and economic techniques to achieve microcapsules with high yield, uniform coating and better entrapment efficiency leading to improved taste masking (Stange et al, 2014 ; Keser et al, 2018 ; Ghimire et al, 2018 ). In the present study, we sought to develop dry syrup formulation containing microencapsulated KCl which would not only mask the taste but also offer the advantages such as convenience of handling, lesser weight per container and overall better stability.…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of taste masked dry syrup formulation of potassium chloride

Kulkarni

Vishwakarma²,

Sen³

et al. 2019

AAPS Open

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Potassium chloride (KCl) syrup is widely used for the oral treatment of the hypokalemia. However, it is associated with unacceptable taste. In the present study, we sought to develop a palatable and easy to reconstitute KCl dry syrup as a commercially viable alternative to currently available KCl syrup. We explored the potential of Eudragit E100 as a taste-masking polymer to coat and improve the palatability of the KCl. With the help of fluid bed processor, KCl was coated with the solution containing varying amounts of Eudragit E100 (4, 6, 10 and 15%). Coating with 10% polymer solution enabled optimal fluid bed processing, higher entrapment of the KCl (81%) and better in vitro release profile in 0.1 N HCl and pH 6.8 phosphate buffer. A dry syrup formulation containing Eudragit E100 coated KCl with good physical and chemical stability in dry and reconstituted state was developed. The palatability of the optimized formulation and commercially available KCl syrup was evaluated using the Electronic Taste Sensing Machine. The developed formulation showed~ 2-fold better taste-masking compared to the commercial KCl syrup. Thus, present investigation describes the development of an effective alternative to the current KCl syrup that can offer better palatability, stability and patient compliance.

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Section: Discussionmentioning

confidence: 99%

Development and evaluation of taste masked dry syrup formulation of potassium chloride

Kulkarni

Vishwakarma²,

Sen³

et al. 2019

AAPS Open

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“…During the past several decades, polymeric excipients have provided numerous strategies for developing new dosage forms with all sorts of drug-controlled release profiles [ 1 , 2 , 3 , 4 ]. Among them, polymeric coating is one of the most popular strategies for modifying the drug release kinetics in both the traditional pharmaceutical industry and also the advanced laboratory nanomethods [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Particularly in nanopharmaceutics, the simple and robust nanocoating methods are highly desired [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Huang

Hanlin

et al. 2020

Nanomaterials

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In nanopharmaceutics, polymeric coating is a popular strategy for modifying the drug release kinetics and, thus, new methods for implementing the nanocoating processes are highly desired. In the present study, a modified coaxial electrospraying process was developed to formulate an ultra-thin layer of ethyl cellulose (EC) on a medicated composite core consisting of tamoxifen citrate (TAM) and EC. A traditional single-fluid blending electrospraying and its monolithic EC-TAM nanoparticles (NPs) were exploited to compare. The modified coaxial processes were demonstrated to be more continuous and robust. The created NPs with EC coating had a higher quality than the monolithic ones in terms of the shape, surface smoothness, and the uniform size distribution, as verified by the SEM and TEM results. XRD patterns suggested that TAM presented in all the NPs in an amorphous state thanks to the fine compatibility between EC and TAM, as indicated by the attenuated total reflection (ATR)-FTIR spectra. In vitro dissolution tests demonstrated that the NPs with EC coating required a time period of 7.58 h, 12.79 h, and 28.74 h for an accumulative release of 30%, 50%, and 90% of the loaded drug, respectively. The protocols reported here open a new way for developing novel medicated nanoparticles with functional coating.

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Development and evaluation of taste-masked pediatric minitablet formulations with bitter model drugs

Cited by 2 publications

References 0 publications

Development and evaluation of taste masked dry syrup formulation of potassium chloride

Development and evaluation of taste masked dry syrup formulation of potassium chloride

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

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