Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion

Brabander, C De; Vervaet, Chris; Remon, Jean Paul

doi:10.1016/s0168-3659(03)00075-0

Cited by 94 publications

(34 citation statements)

References 18 publications

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“…The results of drug release in the present study were consistent with previous studies, which also reported that the amount of drug release was inversely proportional to the polymer concentration in prepared matrix tablets [11][12][17][18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 92%

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Zheng¹,

Wang²,

Du³

2015

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 92%

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Zheng¹,

Wang²,

Du³

2015

Trop. J. Pharm Res

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“…Several matrix based sustained release products of aceclofenac utilizing hydrophilic and hydrophobic polymers have been reported [7][8][9][10][11][12][13]. Polymer matrix systems have the advantages of prolonging drug release and reducing adverse effects in patients.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Ghosh¹,

Barik²

2010

Trop. J. Pharm Res

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Purpose: The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac using ethyl cellulose, guar gum and various grades of cellulose polymers. Methods: Possible drug-excipient interaction was evaluated by high performance liquid chromatography (HPLC) and Fourier infrared spectroscopy (FTIR). The tablets prepared were assessed for their physicochemical, in vitro drug release at pH1.2, 4.5, 6.8 and 7.5 and stability characteristics. Comparison with a 'once daily' commercial aceclofenac product was made in the in vitro studies. Results: There was no interaction between aceclofenac and the polymers used as excipients. Furthermore, the physicochemical properties of the tablets were satisfactory. The release profile of one of the formulated aceclofenac tablets (F7), which contained hydroxypropyl methyl cellulose (HPMC K4M), was statistically similar (p < 0.05) to that of the commercial aceclofenac brand in all the dissolution media. The formulated products ware stable and showed no changes in physical appearance, drug content, or dissolution pattern after storage at 40 o C /75 %RH for 6 months. Conclusion:The results indicate that it is feasible to achieve a stable 'once daily' sustained release aceclofenac tablet formulation by using HPMC K4M of 4000cps viscosity grade as matrix material.

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“…Early work by De Brabander et al (2000) described the preparation of matrix mini-tablets which was followed by further investigations into the properties of sustained release mini-matrices manufactured from ethyl cellulose, HPMC and ibuprofen [32,33]. Extruded mini tablets showed minimised risk of dose dumping, reduced inter-and intra-subject variability.…”

Section: Formulation Research and Developments To Datesmentioning

confidence: 99%

Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications

Maniruzzaman¹,

Douroumis²,

Boateng³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion

Cited by 94 publications

References 18 publications

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac

Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications

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