Development and Evaluation of [11C]I-58: A Novel PET Radiotracer Targeting BRD4 BD2 for Advanced Epigenetic Imaging
Yanli Wang,
Yongle Wang,
Yulong Xu
et al.
Abstract:The paired bromodomains (BD1 and BD2), located in the
bromodomain
and extra-terminal (BET) family proteins, perform specific functions
in gene transcriptional control and expression. Targeting specific
bromodomains with inhibitors holds promise for achieving therapeutic
benefits with reduced side effects. However, the comprehension of
this target related to the disease is still restricted. Positron emission
tomography (PET) imaging is a powerful tool that provides a valuable
avenue for exploring the BD2 bromod… Show more
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