Spraying is one of the most effective and efficient techniques for applying spray liquid to protect crops. The nozzle is a major component in determining the amount of spray applied to an area, the uniformity of application, the coverage obtained on the target surface and the amount of potential drift. Hollow cone, solid cone and 3D action nozzles were selected for the study, which were widely used by the local farmers for cotton crop. The selected nozzles were evaluated in spray patternator for different operating parameters. The operational parameters selected for the study were operating pressure and height of nozzle. The parameters were optimized by using CCRD Response Surface Methodology. The maximum discharge of 1.86, 2.46 and 3.20 l min -1 was obtained at hollow cone, solid cone and 3D action nozzles, respectively at operating pressure of 1000 kPa and nozzle height of 0.4 m. Minimum droplet size of 114 µm was obtained for hollow cone nozzle at operating pressure of 1000 kPa and nozzle height of 0.4 m. The minimum spray uniformity of 1.46, 1.79 and 1.39 was obtained for hollow cone, solid cone and 3D action nozzles, respectively at 912 kPa operating pressure and 0.26 m height of spray. The maximum droplet density of 156, 105 and 85 numbers per cm -2 were obtained at 1000 kPa operating pressure and 0.4 m nozzle height for hollow cone, solid cone and 3D action nozzle, respectively. The CV of volumetric distribution across all three selected nozzles was varied from 6.10 to 18.60 per cent. A hollow cone nozzle was optimized to be operated at 626 kPa operating pressure and 0.56 m nozzle height with coefficient of variation in volumetric distribution of 11.31 per cent with a desirability level of 0.778.