Development and evaluation of PLGA polymer based nanoparticles of quercetin

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

“…Zhang et al [94] aimed to improve the oral absorption of baicalin, which has low solubility and poor permeability, by using a micellar formulation comprised of the carriers Pluronic P123 copolymer and sodium taurocholate. Sustained release profile of baicalin-loaded mixed micelles, in in vitro drug release experiment, held in several pH conditions, showed 14% drug released after 2 h in gastric conditions and 54% release within 48 h in intestinal conditions, compared to 34% and 79% release [105], nanoparticles [106][107][108][109][110], phytosome [111], nanoliposome [112], mixed micelles [113,114], SNEDDS [115,116], nanocarrier [117,118], nanoemulsion [119], nanosuspension [ Mixed micelles [129,130], nanoparticles [131,132], solid dispersion [133,134] , SNEDDS [135] , SMEDDS [136], lipid carrier [137], copolymeric micelles [138], exosomes [139] Naringenin DENV, HCV SNEDDS [140], solid dispersion [141], nanoparticles [142,143] , liposome [144], nanosuspension [145,146] In vitro uptake studies, carried out with a caco-2 cell line, determined the absorption of baicalin within the mixed micelles and verified their internalization ability. Baicalin-loaded ST-P123-MMs formulation achieved high oral bioavailability (Fig.…”

<p>Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats</p>

“…Thermal behavior study is a useful tool to assess whether drug particles have been encapsulated in polymeric matrices. 13 The DSC curve of pure APM was compared with that of different developed APM-loaded PLGA NPs (F1-F3) as shown in Figure 2. A sharp endothermic peak corresponding to 159.4°C was obtained in the case of free APM, which was found to be much closer to that reported in the literature.…”

“…To extend the drug-release time, reduce the frequency of administration, and improve the efficiency of drug as well as patient compliance, various drugs are encapsulated in biodegradable PLGA nanoparticles (PLGA NPs). [13][14][15] The sustained release time of PLGA NPs can be programmed by optimizing particle, size, morphology, and molecular weight of PLGA. 16 A few drug-delivery systems such as topical preparation, 17,18 extended release tablets, 9 and nail lacquers 19 with APM have been investigated in order to enhance its in vitro dissolution rate, efficacy, PK profile, and in vivo bioavailability.…”

RETRACTED ARTICLE: Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia

“…Despite the efficacy in treatment of cerebral ischaemia, QUR due to poor solubility and absorption along with rapid metabolism and quick elimination poses the drawback of low serum and tissue concentrations [12,13]. In order to overcome the drawback, different strategies in terms of formulations and route of administration have been applied.…”