Development and evaluation of mucoadhesive bigel containing tenofovir and maraviroc for HIV prophylaxis

Ilomuanya, Margaret O.; Hameedat, Ayotunde T.; Akang, E. E. U.; Ekama, Sabdat Ozichu; Silva, Boladale O.

doi:10.1186/s43094-020-00093-3

Cited by 22 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because there was a 1 log10 change in Lactobacilli crispatus viability, the bigel formulations were nontoxic to the human vagina. [12] The aim of current research concludes that the bigel formed is stable and might be used to treat vaginal infections.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Development of Bigels Containing Antifungal Agent for Vaginal Infection

NNensi

2022

Preprint

View full text Add to dashboard Cite

Objective Bigels are developed and are unique semi-solid formulations that have captivated the interest of many researchers due to their significant benefits over ordinary gels. The goal of this research work was to create and characterize new bigels for drug delivery applications by combining Hydroxypropyl methylcellulose hydrogel with sorbitan monostearate oil (coconut and olive) based organogel. The microscopy revealed the presence of both aqueous & oil phases as bigel. Methods The hydrogels and organogels were prepared individually and then the bigels were prepared by mixing hydrogel and organogel in a defined ratio and then they were evaluated using physiochemical tests, in-vitro drug release, microscopy, etc. The microstructures and physicochemical characteristics of the bigel were tested using microscopy, viscosity measurement, mechanical analysis, and differential scanning calorimetry analysis. Results Tube inversion tests reveal that the bigel doesn’t flow under its own weight till 167 mins. The microscopy suggested that the gels exhibited fiber-like structures due to the trapping of the organogel inside hydrogel molecules; this entrapment was demonstrated to be uniformly accomplished, resulting in formulation stability, and the DSC study reveals that the terbinafine is not decomposed also after formulating in bigel, and the terbinafine bigel was also found to be stable. The drug-loaded gels demonstrated effective antibacterial activity against Candida species. The formulated bigel shows initial release in 2 hours and slowly release later in 4 hours. The formed bigel is found to be stable after 3 months with a pH range of 7.07 ± 0.04, showing good spreadability and drug content was 99.99 ± 0.75. Conclusions Terbinafine, the drug of preference for the treatment of bacterial vaginosis, demonstrated diffusion-mediated drug release when placed into bigels. In general, the produced bigels might be employed as delivery vehicles for drugs delivered vaginally.

show abstract

Section: Discussionmentioning

confidence: 92%

“…[11] Margaret O. Ilomuanya et al (2020) developed a dual compartment bigel containing maraviroc and tenofovir. Bigel was discovered to be stable and nontoxic to the vaginal and rectal epithelium, and it actively prevented HIV transmission.…”

Section: Discussionmentioning

confidence: 99%

Development of Bigels Containing Antifungal Agent for Vaginal Infection

NNensi

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Bigel was shown to be stable and nontoxic to the vaginal and rectal epithelium, as well as actively preventing HIV transmission. The bigel formulations were non-toxic to the human vagina since there was a 1 log10 change in Lactobacilli crispatus viability [12].…”

Section: Stability Of the Hydrogel Organogel And Bigel With Physioche...mentioning

confidence: 99%

Development of Bigels Containing Antifungal Agent for Vaginal Infection

Raytthatha¹,

VYAS²

2022

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Bigels are unique semi-solid preparations that have piqued the focus of numerous scientists owing to their significant advantages over ordinary gels. The purpose of this study was to develop and characterize innovative Bigels for applications in drug delivery by combining Hydroxypropyl methylcellulose hydrogel and sorbitan monostearate, oils like coconut and olive-based organogel. The existence of both aqueous and oil phases as bigel was revealed by microscopy. Methods: Hydrogels and organogels were prepared separately, and bigels were formed by combining hydrogel and organogel in a predetermined ratio. They were then analyzed employing various physicochemical tests i. e in vitro drug release, microscopy, and other techniques. Microscopy, viscosity measurement, mechanical analysis, and differential scanning calorimetry were used to examine the bigel's microstructures and physicochemical properties. Results: Tube inversion tests reveal that the bigel doesn’t flow under its own weight till 167 min. The microscopy suggested that the gels exhibited fiber-like structures due to the trapping of the organogel inside hydrogel molecules; this entrapment was demonstrated to be uniformly accomplished, resulting in formulation stability, and the DSC study reveals that the terbinafine is not decomposed also after formulating in bigel, and the terbinafine bigel was also found to be stable. The drug-loaded gels demonstrated effective antibacterial activity against Candida species. The formulated bigel shows initial release in 2 h and slowly release later in 4 h. The formed bigel is found to be stable after 3 mo with a pH range of 7.07±0.04, showing good spreadability and drug content was 99.99±0.75. Conclusion: Terbinafine, the drug of preference for the treatment of bacterial vaginosis, demonstrated diffusion-mediated drug release when placed into bigels. In general, the produced bigels might be employed as delivery vehicles for drugs delivered vaginally.

show abstract

“…raltegravir) and entry inhibitors (i.e. maraviroc) (Date et al, 2012;Gallay et al, 2017;Ilomuanya et al, 2020). Many of these drugs have been formulated as electrospun fibers.…”

Section: Sexually Transmitted Infectionsmentioning

confidence: 99%