Development and evaluation of methotrexate nanocomposites using Β-cyclodextrins/alginate polymers and response surface methodology
A. M. Hussein,
S. H. Hussein-Al-Ali
Abstract:β-cyclodextrin and alginate polymers have been extensively investigated for their use in drug delivery systems. β-Cyclodextrin-alginate nanoparticles (CD/Alg) as an innovative drug carrier was the preapared by ionic chelation method. Methotrexate (MTX) as model drug was loaded onto the β-CD/Alg nanoparticles to form MTX-CD/Alg nanocomposites, via ionic interactions. The study was to investigate the changes in independent variables (concentration of CD, Alg and CaCl2) loading efficiency and particle size using … Show more
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