BACKGROUND: Despite national recommendations for
early transition to enteral antimicrobials, practice variability
has existed at our hospital.
OBJECTIVE: The aim of this study was to increase the
proportion of enterally administered antibiotic doses
for Pediatric Hospital Medicine patients aged >60
days admitted for uncomplicated community-acquired
pneumonia or skin and soft tissue infections from 44% to
75% in eight months.
METHODS: This quality improvement study was
conducted at a large, urban, academic children’s hospital.
The study population included Hospital Medicine patients
aged >60 days with diagnoses of pneumonia or skin and
soft tissue infections. Interventions included education
on intravenous and enteral antibiotic charge differentials,
documentation of transition plan, structured discussions
of transition criteria, and real-time identification of failures
with feedback. Our process measure was the total number
of enteral antibiotic doses divided by all antibiotic doses
in patients receiving enteral medications on the same day.
An annotated statistical process control chart tracked the
impact of interventions on the administration route of
antibiotic doses over time. Additional outcome measures
included antimicrobial costs per patient encounter using
average wholesale prices and length of stay.
RESULTS: The percentage of enterally administered
antibiotic doses increased from 44% to 80% within eight
months. Antimicrobial costs per patient encounter and
the associated standard deviation of costs for our target
diagnoses decreased by 70% and 84%, respectively.
Average length of stay did not change.
CONCLUSIONS: Standardized communication about
criteria for transition from intravenous to enteral antibiotics
can lead to earlier transitions for patients with pneumonia
or skin and soft tissue infections, subsequently reducing
costs and prescribing variability.