Development and evaluation of extended release ciprofloxacin HCl ocular inserts employing natural and synthetic film forming agents

Dawaba, Hamdy M.; Dawaba, Aya M.

doi:10.1007/s40005-018-0400-x

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…The Increase in PG (plasticizer) in both the drug reservoir (above 1.25% v /v) and RCM (above 2.5%) did not significantly affect the in vitro release of VLD, as shown from trial experiments (p > 0.05). PG interposes between every individual strand of the used polymer, and the breakdown of the polymer-polymer bonds results in converting the OCUs into a flexible, highly porous, and less cohesive structure ( Dawaba and Dawaba, 2019 ). When the in vitro release data were plotted according to the Zero-order equation, VLD-SLNPs-OCUs showed good linearity with higher correlation than First-order and Higuchi–Diffusion models, Indicating Zero-order release model for all VLD-SLNPs-OCUs formulations as shown in Table S5 (supplementary materials file).…”

Section: Resultsmentioning

confidence: 99%

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Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy

Ramadan,

Elsayed,

Elsayed

et al. 2024

International Journal of Pharmaceutics: X

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Section: Resultsmentioning

confidence: 99%

“…The electrodes of a digital pH sensor (JENWAY 3310, UK) were positioned on the surface of the OCU under investigation, and the system was allowed to equilibrate for one minute. After that, the pH levels were recorded (n = 3) ( Dawaba and Dawaba, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy

Ramadan,

Elsayed,

Elsayed

et al. 2024

International Journal of Pharmaceutics: X

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“…Although the application of su-SEDDSs is primarily intended to improve the absorption of poorly water-soluble drugs, it would also be desirable to provide sustained-release action in the case of low-dose drugs with short biological half-lives that require frequent dosing [14,[248][249][250]. As the prolongation of supersaturation is important for increasing absorption, the application of controlled release DDS in SEDDS has recently attracted much attention [5,131].…”

Section: Application Of Controlled-release Technology In Su-seddssmentioning

confidence: 99%

Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems

Park

Kim

2020

Pharmaceutics

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Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact that the inclusion of precipitation inhibitors (PIs) within SEDDSs helps maintain drug supersaturation after dispersion and digestion in the gastrointestinal tract. This improves the BA of drugs and reduces the variability of exposure. In addition, the formulation of solid su-SEDDSs has helped to overcome disadvantages of liquid or capsule dosage form. This review article discusses, in detail, the current status of su-SEDDSs that overcome the limitations of conventional SEDDSs. It discusses the definition and range of su-SEDDSs, the principle mechanisms underlying precipitation inhibition and enhanced in vivo absorption, drug application cases, biorelevance in vitro digestion models, and the development of liquid su-SEDDSs to solid dosage forms. This review also describes the effects of various physiological factors and the potential interactions between PIs and lipid, lipase or lipid digested products on the in vivo performance of su-SEDDSs. In particular, several considerations relating to the properties of PIs are discussed from various perspectives.Pharmaceutics 2020, 12, 365 2 of 57 intraluminal supersaturation and the biorelevance of supersaturation assays will be addressed. Finally, we will make suggestions for the successful development of su-SEDDs.There are many review articles that give useful information about the nature and application of supersaturable drug delivery systems or conventional SEDDSs. However, these reviews cover only a limited range of su-SEDDSs. Therefore, this review, which includes the current status of technology focused only on su-SEDDSs, is a valuable addition to the previous review literature because no review article currently covers such a wide range of su-SEDDSs. Conventional Solubilized SEDDSsThere has been a steady increase in the number of new drug candidates (almost 40%) that are highly hydrophobic and poorly water-soluble. The oral bioavailability of poorly water-soluble drugs is hindered by low solubility and slow dissolution in the aqueous environment of the GIT. Thus, it is a great challenge for pharmaceutical scientists to overcome the inherent slow dissolution and poor oral absorption of hydrophobic drugs [1][2][3][4]. SEDDSs have emerged as a promising approach to improving the biopharmaceutical performance of hydrophobic drugs by enhancing their bioavailability [5,6].An SEDDS is a pre-concentrate composed of a drug, oils, surfactants, and sometimes co-solvents and/or co-surfactan...

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“…In particular, among the formulations containing lubricants, F3 and F4 exhibited better precipitation-inhibiting effects than F2. It was reported that the stability of protein in thermal conditions increases when polymers or sugars are added [40][41][42][43][44]. This thermal resistance can maintain the quality of the eye drop when the formulation is exposed to unexpected thermal conditions.…”

Section: Long-term and Accelerated Testmentioning

confidence: 99%

Achyranthis radix Extract-Loaded Eye Drop Formulation Development and Novel Evaluation Method for Dry Eye Treatment

et al. 2020

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Recently, Achyranthis radix extract has been studied as a therapeutic agent for dry eye disease that occurs from fine dust. The aim of this study was the development of Achyranthis radix extract-loaded eye drop formulations using lubricants, generally used for artificial tear eye drops. Ecdysterone was used as a marker compound for Achyranthis radix extract and 1% Achyranthis radix extract solution contained 14.37 ± 0.04 μg/mL of ecdysterone. Before formulation studies, a new method was performed to evaluate pigmentation, which might be caused by eye drops of herbal extract. A comparative study of the water retention ability of each formulation and ability to prevent the death of conjunctival epithelial cells in dry conditions was conducted. Moreover, treatment of Achyranthis radix extract (USL) eye drop formulation exhibited a significant inhibitory effect on inflammation in a concentration-dependent manner. The long-term and accelerated stability tests showed that lubricants could contribute to the stability of herbal extracts in solution. In conclusion, hyaluronic acid showed a good effect on the development of eye drop formulation using Achyranthis radix extracts for treating dry eye disease.

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Development and evaluation of extended release ciprofloxacin HCl ocular inserts employing natural and synthetic film forming agents

Cited by 7 publications

References 25 publications

Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy

Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy

Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems

Achyranthis radix Extract-Loaded Eye Drop Formulation Development and Novel Evaluation Method for Dry Eye Treatment

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