Development and evaluation of diclofenac sodium thermorevesible subcutaneous drug delivery system

Nasir, Fazli; Iqbal, Zafar; Khan, Jamil; Khan, Abad; Khuda, Fazli; Ahmad, Lateef; Khan, Amirzada; Khan, Abbas; Dayoo, Abdullah; Roohullah,

doi:10.1016/j.ijpharm.2012.10.009

Cited by 32 publications

(20 citation statements)

References 25 publications

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“…The Ch/DSF hydrogel was transparent at the experimental temperature (25 °C), which proves that the added ingredients are homogeneously mixed. 21 It was observed that the hydrogel became turbid at body temperature in comparison to the initial sol ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 97%

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

2020

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A thermosensitive, physically cross-linked injectable hydrogel was formulated for the effective and sustained delivery of disulfiram (DSF) to the cancer cells as there is no hydrogel formulation available until now for the delivery of DSF. As we know, hydrogels have an advantage over other drug delivery systems because of their unique properties, so we proposed to formulate an injectable hydrogel system for the sustained delivery of an anticancer drug (DSF) to cancer cells. To investigate the surface morphology, a scanning electron microscope study was carried out, and for thermal stability of hydrogels, TGA (thermogravimetric analysis) and DSC (differential scanning calorimetry) were performed. The rheological behavior of hydrogels was evaluated with the increasing temperature and time. These developed hydrogels possessing excellent biocompatibility could be injected at room temperature following rapid gel formation at body temperature. The swelling index and in vitro drug release studies were performed at different pH (6.8 and 7.4) and temperatures (25 and 37 °C). The cell viability of the blank hydrogel, free DSF solution, and Ch/DSF (chitosan/DSF)-loaded hydrogel was studied by MTT assay on SMMC-7721 cells for 24 and 48 h, which exhibited higher cytotoxicity in a dose-dependent manner in contrast to the free DSF solution. Moreover, the cellular uptake of DSF-loaded hydrogels was observed stronger as compared with free DSF. Hence, chitosan-based hydrogels loaded with DSF possessing exceptional properties can be used as a novel injectable anticancer drug for the sustained delivery of DSF for long-term cancer therapy.

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Section: Resultsmentioning

confidence: 97%

Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier

2020

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“…Kinetically-frozen nanoparticles have been used to successfully image the intestine, giving high intensity images and no ill effect in a mouse model [ 143 ]. Hydrogel formation also allows for targeted subcutaneous drug delivery [ 159 , 160 ]. The influence of the structure of poloxamer-based vehicles on drug delivery in various administration routes draws connections between self-assembly, vehicle structure and resulting delivery mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Formulation of Poloxamers for Drug Delivery

Bodratti

Alexandridis

2018

JFB

425

267

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Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals. Current challenges facing nanomedicine revolve around the transport of typically water-insoluble drugs throughout the body, followed by targeted delivery. Judicious design of drug delivery systems leads to improved bioavailability, patient compliance and therapeutic outcomes. The rich phase behavior (micelles, hydrogels, lyotropic liquid crystals, etc.) of poloxamers makes them amenable to multiple types of processing and various product forms. In this review, we first present the general solution behavior of poloxamers, focusing on their self-assembly properties. This is followed by a discussion of how the self-assembly properties of poloxamers can be leveraged to encapsulate drugs using an array of processing techniques including direct solubilization, solvent displacement methods, emulsification and preparation of kinetically-frozen nanoparticles. Finally, we conclude with a summary and perspective.

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“…Long-term, zero-order delivery of DS is considered an ideal regimen for the treatment of chronic inflammatory disorders [21]. In this sense, microfabricated devices have attracted interest in the field of zeroorder drug delivery: the geometry of the drug diffusion barrier and reservoir can be precisely tailored; thus, highly controlled drug delivery would be possible.…”

Section: Discussionmentioning

confidence: 99%