Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule

Nie, Xiangjiang; Wang, Bin; Hu, Rongfeng; Lu, Wenjie; Chen, Jiayi; Liu, Songlin; Jin, Dong; Sun, Chuan-bin; Gao, Song; Guo, Yuxing; Fang, Wenyou; Hao, Haiping

doi:10.1208/s12249-019-1603-9

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…Also, care must be taken in the amount of CD used in the formulation, as an excess of CDs could hinder the absorption of the drug through the GI tract [ 68 , 69 ]. Nonetheless, the fascinating recent research devoted to oral CD-based pharmaceutical technologies will certainly maintain the increasing trend observed herein [ [70] , [71] , [72] , [73] , [74] , [75] ].…”

Section: Resultsmentioning

confidence: 82%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.

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Section: Resultsmentioning

confidence: 82%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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“…the Compound Danshen Dripping Pills are produced based on TCM theory combined with modern biotechnology, and the main components are Salvia miltiorrhiza, Panax notoginseng, and borneol. They are characterized by small dosage, rapid absorption, and rapid onset of action, and can rapidly achieve the effects of cooling the blood, hemostasis, eliminating stasis, and dispersing pain after oral administration (21,22).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Compound Danshen Dripping Pills combined with western medicine in the treatment of diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Huang

et al. 2021

Ann Palliat Med

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Background: The Compound Danshen Dripping Pills have been widely used in the treatment of DR, but there is a lack of systematic review of reports on this topic. To explore the efficacy of Compound Danshen Dripping Pills combined with western medicine in the treatment of diabetic retinopathy, we conducted a meta-analysis. Methods: Randomized controlled trials published in the Chinese Medical Literature Database (CBM), Embase, PubMed, and Medline databases from January 2010 to August 2021 were searched. After screening the qualified literature, literature quality was evaluated by the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analysis was performed on outcome measures including effective rate, visual field gray value, hemangioma volume, hemorrhagic plaque area, and visual acuity after diabetic retinopathy treatment with Compound Danshen Dripping Pills using Revman 5.3 analysis software to comprehensively evaluate the utility of Compound Danshen Dripping Pills. Results: A total of 167 documents were preliminarily searched, and 8 studies involving 524 patients were included for meta-analysis. Meta-analysis showed that the statistical value of the effective rate of diabetic retinopathy treatment in the intervention group and control group was OR =5.00, 95% CI (2.84, 8.83), P<0.0001. The statistical value of visual field gray value comparison was MD =−0.93, 95% CI (−0.98, −0.89), P<0.00001. The statistical value of hemangioma volume was MD =−3.16, 95% CI (−3.48, −2.84), P<0.00001. The statistical value of hemorrhagic plaque area comparison was MD =−0.65, 95% CI (−0.97, −0.32), P<0.0001. The statistical value of visual acuity comparison was MD =0.15, 95% CI (0.10, 0.19), P<0.00001. Discussion: The Compound Danshen Dripping Pills combined with western medicine are effective and safe in the treatment of diabetic retinopathy.

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“…The SEM analysis of tablet dissolution showed that the significant porosity during the dissolution is the result of the leaching of water-soluble additives during dissolution [38]. The multiple parameters like weight gain (coating), agitation speed, orifice diameter, coating membrane thickness pH of media showed negligible effect on drug release [39][40][41][42][43][44]. As per the expectations of in vitro drug release results, in vivo also TSP osmotic tablet (60 mg) shows zero-order release with efficient plasma concentration of drug over 24-h period as compared to once a day (o.d) extended-release commercially available TSP capsule 60 mg (Sanctura XR ® capsules, 60 mg) in the beagle dog.…”

Section: Discussionmentioning

confidence: 99%

Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Gundu

Pekamwar

Shelke³

et al. 2021

Futur J Pharm Sci

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Background The research was aimed with an approach to formulate biphasic extended-release system of trospium chloride resulting in controlled release of drug up to 24 h with prospects of better control on urinary frequency, efficacy, tolerability, and improved patient compliance. The push–pull osmotic pump (PPOP) bi-layered tablet of trospium chloride (60 mg) was developed with the use of immediate-release polymers in the pull layer (30 mg drug) and polyethylene oxide in the push layer (remaining 30 mg drug). The tablet was formulated by compression after non-aqueous granulation, seal coating, and semipermeable coating. The tablet prepared was laser drilled to create an orifice for drug release. Results Comparative in vitro dissolution and in vivo pharmacokinetic analysis of available marketed formulations demonstrated the complete drug release within 16–18 h; hence the developed biphasic extended-release system has its great importance as it provides zero-order release up to 24 h. Conclusions The developed biphasic extended-release drug delivery system of trospium chloride provides the drug release for 24 h with effective plasma concentration in comparison with the available marketed formulation. Extended release of drug from the developed formulation provides scope for its promising application in the treatment of overactive bladder (OAB).

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Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule

Cited by 11 publications

References 34 publications

Technological evolution of cyclodextrins in the pharmaceutical field

Technological evolution of cyclodextrins in the pharmaceutical field

Efficacy of Compound Danshen Dripping Pills combined with western medicine in the treatment of diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

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