Development and Evaluation of a New Apparatus for Continuous Perfusion of Isolated Perfused Pig Heart

An, Mi Young; Canel, Emmanuelle P; Jang, In Ho; Revel, D.; Fossum, Theresa W.; Chung, Nam Sik; Janier, M.

doi:10.4142/jvs.2002.3.3.219

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2016

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“…32 The porcine model was chosen on purpose because these hearts are similar to human hearts concerning size, structure, and function. 33 Our study provides information about intraischemic GJU in relation to edema formation but the relevance of changes in both parameters on the quality of postischemic reperfusion was not investigated.…”

Section: Limitationsmentioning

confidence: 95%

Age-related differences of intraischemic gap junction uncoupling in hearts during ischemia

Lueck

Delis

Minor

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

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Intraischemic formation of edema and earlier GJU indicate faster intraischemic changes in neonates compared with adults. Intraischemic GJU and determination of intracellular water shifts are an experimental approach to establish the period of life-threatening damage. Because both parameters are linked and occur significantly earlier in neonates, they distinctly demonstrate the lower ischemia tolerance of neonatal hearts as both events interact.

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Section: Limitationsmentioning

confidence: 95%