Development and evaluation of a robotics-based system for glycosylated hemoglobin analysis

Herold, Christopher D.; Holman, Jeffrey W.; Andree, K; Felder, Robin A.; Herold, David A.

doi:10.1016/0169-7439(93)89009-y

Cited by 1 publication

(1 citation statement)

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“…To a large extent, these sample-handling practices disappeared with the introduction of plasticware such as microtiter plates, microcentrifuge tubes, and disposable pipette tips. It was the latter technology that provided the model for automation in current commercial systems, such as the Beckman Biomek 2000 [13], Hamilton Microlab 2200 [18], Hewlett-Packard (now Sagian/Beckman Instruments) ORCA [19], Packard Instruments MultiPROBE [14], and Zymark [20]. Although quite successful in both manual and automated modes for samples in the 5-10-L range, this technology is less well suited than the capillary approach for smaller samples.…”

Section: A Background and Significancementioning

confidence: 99%

A biomechatronic fluid-sample-handling system for DNA processing

Meldrum

1997

IEEE/ASME Trans. Mechatron.

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An automated biomechatronic small fluid sample preparation system for deoxyribonucleic acid (DNA) processing has been developed in the Genomation Laboratory of the Department of Electrical Engineering, University of Washington, Seattle, WA. The system automates steps necessary to prepare DNA for sequencing, using sample volumes ten times smaller than the current state-of-the-art manual and automated instrumentation. This will significantly reduce the time and cost of DNA sequencing and will help the Human Genome Project meet its goal of determining all three billion bases of human DNA sequence by the year 2005. The biomechatronic system comprising electromagnetic actuators, piezoceramic actuators, pneumatic pumps, linear mechanisms, thermal controllers, optical sensors, electronics, computer control, and software is described in detail. Successful experimental results, including restriction enzyme digests and polymerase chain reactions (PCR's) performed with this novel system, are presented.

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Section: A Background and Significancementioning

confidence: 99%

A biomechatronic fluid-sample-handling system for DNA processing

Meldrum

1997

IEEE/ASME Trans. Mechatron.

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show abstract

Development and evaluation of a robotics-based system for glycosylated hemoglobin analysis

Cited by 1 publication

References 8 publications

A biomechatronic fluid-sample-handling system for DNA processing

A biomechatronic fluid-sample-handling system for DNA processing

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