Development and clinical application of an evidence-based pharmaceutical care service algorithm in acute coronary syndrome

Kang, Ji Eun; Yu, Jin; Choi, Jang-Hwan; Chung, Ick Mo; Pyun, Wook Bum; Kim, S. A.; Lee, E. K.; Han, Nayoung; Yoon, Jeong Hyun; Oh, Jung Mi; Rhie, Sandy Jeong

doi:10.1111/jcpt.12665

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…This result was consistent with the results of other studies assessing chronic conditions ( Hohmeier et al, 2019 ; Thompson et al, 2020 ; Wang et al, 2021 ). But limited studies showed the efficacy of MTM services in patients with non-chronic conditions, like cancer ( Dürr et al, 2021 ) and acute coronary syndrome ( Kang et al, 2018 ). These results showed possibility of heterogeneity in the type of diseases and indicated the need for additional evidence to support the efficacy of MTM services for managing patients with non-chronic disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical, economic and humanistic outcomes of medication therapy management services: A systematic review and meta-analysis

et al. 2023

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Background: Medication therapy management (MTM) services is a method that can effectively improve patients’ conditions, but the efficacy of economic and humanistic outcomes remain unclear. This systematic review and meta-analysis aim to use economic, clinical and humanistic outcomes to evaluate the multi-benefits of MTM services.Method: A systematic review and meta-analysis was conducted by retrieving PubMed, EMBASE, the Cochrane Library and ClinicalTrial.gov from the inception to April 2022. There were two reviewers screening the records, extracting the data, and assessing the quality of studies independently.Results: A total of 81 studies with 60,753 participants were included. MTM services were more effective in clinical outcomes with decreasing the rate of readmission (OR: 0.78; 95% CI: 0.73 to 0.83; I2 = 56%), emergency department visit (OR: 0.88; 95% CI: 0.81 to 0.96; I2 = 32%), adverse drug events (All-cause: OR: 0.68; 95% CI: 0.56 to 0.84; I2 = 61%; SAE: OR: 0.51; 95% CI: 0.33 to 0.79; I2 = 35%) and drug-related problems (MD: −1.37; 95% CI: −2.24 to −0.5; I2 = 95%), reducing the length of stay in hospital (MD: −0.74; 95% CI: −1.37 to −0.13; I2 = 70%), while the economic and humanistic outcomes were less effective.Conclusion: Our systematic review and meta-analysis demonstrated that MTM services had great ability to improve patients’ clinical conditions while the efficacy of economic and humanistic outcomes, with some of the outcomes showing high degree of heterogeneity and possible publication bias, required more future studies to provide stronger evidence.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349050], identifier [CRD42022349050].

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