Development and characterization of the voriconazole loaded lipid-based nanoparticles

Füredi, Petra; Pápay, Zsófia Edit; Kovács, Kristóf; Kiss, Borbála Dalmadi; Ludányi, Krisztina; Antal, István; Klebovich, Imre

doi:10.1016/j.jpba.2016.09.047

Cited by 30 publications

(6 citation statements)

References 28 publications

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“…In cutaneous and vulvovaginal candidiasis, ketoconazole dispersed into SLNs showed anti-candida activity [ 209 , 210 ]. Voriconazole, another common anti-fungal drug, was loaded into SLNs, and two studies showed antimycotic activity against C. glabrata when administered ocularly [ 211 , 240 ].…”

Section: Lipid Based Nanoparticlesmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.

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Section: Lipid Based Nanoparticlesmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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“…VCZ is a class II drug with low solubility and high permeability [ 154 , 155 , 156 ]. Low water solubility makes it difficult to administer by different routes of administration [ 157 ]. VCZ is commercially available in tablets, oral suspension, and intravenous solutions [ 158 , 159 , 160 ].…”

Section: Voriconazolementioning

confidence: 99%

“…The ability to improve drug solubility through lipid formulations has also been explored in VCZ delivery systems, to topical [ 160 , 232 ] and ocular administration [ 157 ]. In the study carried out by Andrade, an NLS was developed with 75% encapsulation efficiency that allowed safe release into ocular tissue in ex vivo tests [ 232 ].…”

Section: Nanotechnology-based Voriconazole Delivery Systemsmentioning

confidence: 99%

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

et al. 2023

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Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant to fluconazole, and for infections caused by endemic mycoses, in addition to those that occur in the central nervous system. However, despite its broad activity, using voriconazole has limitations related to its non-linear pharmacokinetics, leading to supratherapeutic doses and increased toxicity according to individual polymorphisms during its metabolism. In this sense, nanotechnology-based drug delivery systems have successfully improved the physicochemical and biological aspects of different classes of drugs, including antifungals. In this review, we highlighted recent work that has applied nanotechnology to deliver voriconazole. These systems allowed increased permeation and deposition of voriconazole in target tissues from a controlled and sustained release in different routes of administration such as ocular, pulmonary, oral, topical, and parenteral. Thus, nanotechnology application aiming to delivery voriconazole becomes a more effective and safer therapeutic alternative in the treatment of fungal infections.

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“…In addition to the possibility of sustained-release, which facilitates patient adherence to fungal infection treatments, one of the goals of using nanotechnology is also related to improving the solubility of voriconazole in aqueous media, or allowing new routes of administration [212,213]. In order to provide new routes of administration for voriconazole besides the oral one, nanotechnology has been explored for ocular [54,214,215,216], pulmonary [53,217,218,219], and nail [220] distribution routes.…”

Section: Voriconazolementioning

confidence: 99%

“…Due to the low water solubility of voriconazole, Füredi et al [216] developed lipid-based nanoparticles by high-pressure homogenization for parenteral administration. The nanoparticles obtained had a size of 81.2 nm and encapsulation efficiency close to 70%, allowing doubling of the solubility of voriconazole.…”

Section: Voriconazolementioning

confidence: 99%

Nanoparticles as a Tool for Broadening Antifungal Activities

Renzi

Campos

Miranda

et al. 2021

CMC

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: The Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.

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Development and characterization of the voriconazole loaded lipid-based nanoparticles

Cited by 30 publications

References 28 publications

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

Nanoparticles as a Tool for Broadening Antifungal Activities

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