Development and Characterization of Silver nanoparticles (AgNPs) using Aqueous leaves broth of <i>Artemisia vulgaris L</i>., and its Anti-fungal activity

Kumararaja, Gayathri; Saneesha, P N; Kumar, Sruthy S; Parveen, V V Shahana; Rahim, Shaikh Fuzail Abdur; Shamna, K V; Shamna, P A; Sundaraganapathy, R; Gayathri, R.

doi:10.5958/0974-360x.2019.00834.5

Cited by 10 publications

(1 citation statement)

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“…Among the various types of metallic nanoparticles used in the controlled release of drugs in the treatment of fungal diseases, silver nanoparticles (AgNP), gold nanoparticles (AuNP), and some metal oxides (MO-NP) stand out. The use of AgNP in antifungal controlled release is desirable due to its capacity to bypass microorganism resistance, which is attributed to its good physicochemical characteristics, large surface area, and easy synthesis and modification (Baygar, Sarac, Ugur, & Karaca, 2019;Halbandge, Mortale, & Karuppayil, 2017;Kumararaja et al, 2019;Melo Jr et al, 2012;Prabhu & Poulose, 2012). it was highlighted that the use of AgNP was able to enhance the activity of the medicinal plant used, with good potential for therapy (Qayyum et al, 2020).…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Marena

Ramos

Carvalho

et al. 2022

Phytotherapy Research

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Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the uncontrolled use of antifungals. It is, therefore, important to develop new methods that contribute to combating fungal diseases in the clinical area. Natural products have considerable potential for the development of new drugs with antifungal activity, mainly due to their biocompatibility and low toxic effect. This promising antimicrobial activity of natural products is mainly due to the presence of flavonoids, terpenes, and quinones, which explains their antifungal potential. Pharmaceutical nanotechnology has been explored to enhance the delivery, selectivity, and clinical efficacy of these products. Nanotechnological systems provide a safe and selective environment for various substances, such as natural products, improving antifungal activity. However, further safety experiments (in vivo or clinical trials) need to be carried out to prove the therapeutic action of natural products, since they may have undesirable, toxic, and mutagenic effects. Therefore, this review article addresses the main nanotechnological methods using natural products for effective future treatment against the main fungal diseases.

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