Development and characterization of rapid dissolving ornidazole loaded PVP electrospun fibers

Tort, Serdar; Yıldız, Ayşegül; Tuğcu-Demiröz, Fatmanur; Akca, Gülçin; Kuzukiran, Ozgur; Acartürk, Füsun

doi:10.1080/10837450.2019.1615088

Cited by 41 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results shown are encouraging and corroborate the results found in the literature (Kim et al, 2004;Tort et al, 2019). Different polymeric systems were evaluated, including poly (vinyl alcohol) (PVA) and AmpB fibers, which obtained the greatest release of the drug to which the hydrophilic nature of the polymer was attributed, as this favors the entry of water in the matrix and provides the solvation of AmpB, therefore there is an association between wettability and release kinetics.…”

Section: Discussionsupporting

confidence: 85%

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

Gonçalves

Rocha

Pires

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The aim of this study was to develop polymeric nanofibers for controlled administration of Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, and activity against Leishmania and Candida species. The core-shell nanofibers incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) and characterized by scanning electron microscopy (SEM), differential scanning calorimetry, X-Ray diffraction, and drug release assay. In vitro leishmanicidal and antifungal activity were also evaluated. Fibrous membranes with uniform morphology and smooth surfaces were produced. The intensity of the diffraction peaks becomes slightly more pronounced, assuming the increased crystallization in PLA/PEG at high AmpB loadings. Drug release occurred and the solutions with nanofibers to encourage greater incorporation of AmpB showed a higher concentration. In the results of the experiment with promastigotes, the wells treated with nanofibers containing concentrations of AmpB at 0.25, 0.5, and 1%, did not have any viable cells, similar to the positive control. Various concentrations of AmpB improved the inhibition of fungal growth. The delivery system based on PLA/PEG nanofibers was properly developed for AmpB, presenting a controlled release and a successful encapsulation, as well as antifungal and antileishmanial activity.

show abstract

Section: Discussionsupporting

confidence: 85%

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

Gonçalves

Rocha

Pires

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Further, electrospinning allows multiple different fluids to be processed simultaneously, leading to fiber products with highly tunable properties [15,16]. Electrospun fibers have been widely explored to generate drug delivery systems, and there are reports in the literature of fast-dissolving [17][18][19][20], extended release [21][22][23], and pH responsive systems [24,25], among many others. Fixed-dose combination formulations have also been prepared by electrospinning [26,27], but there are few studies where multiple drugs have been combined into a single fiber formulation.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Electrospun Levodopa-Carbidopa Fixed-Dose Combinations

2020

View full text Add to dashboard Cite

We report in this work coaxial electrospun fibers with potential applications in the treatment of Parkinson’s disease. The fibers comprise a fixed dose combination (FDC) containing the active ingredients levodopa and carbidopa, loaded in a fast dissolving polyvinylpyrrolidone (PVP) shell and an insoluble but swellable Eudragit® RLPO core. Under appropriate processing conditions we are able to prepare fibers with distinct core/shell architectures and diameters of approximately 400 nm. X-ray diffraction and differential scanning calorimetry analyses revealed that the drugs are dispersed on the molecular level within the polymer carriers, and IR spectroscopy indicated the presence of intermolecular interactions. At pH 1, the composite fibers yields extended release over more than 8 h, with an initial loading dose being freed from the PVP shell and then a sustained release phase following from the insoluble core. This is markedly extended over the release period of the commercial FDC product, and thus the fibers generated here have the potential to be used to reduce the required dosing frequency. Graphic Abstract

show abstract

“…When loaded in free form, CF, 141 AMX, 140 PX and MX 75,142 all showed a burst release, and Ornidazole was even diffused from all of the fibers and released within 5 min. 150 Besides, the releasing speed can also be influenced by drug initial concentrations 139 and the composition in the membranes or scaffolds. 107,140 However, long-term drug release and activity is also quite important.…”

Section: Release Ratementioning

confidence: 99%

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Ren

et al. 2020

J Biomater Appl

View full text Add to dashboard Cite

Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

show abstract

Development and characterization of rapid dissolving ornidazole loaded PVP electrospun fibers

Cited by 41 publications

References 48 publications

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

Fabrication of Electrospun Levodopa-Carbidopa Fixed-Dose Combinations

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Contact Info

Product

Resources

About