Development and characterization of novel electrically conductive PANI–PGS composites for cardiac tissue engineering applications

Qazi, Taimoor H.; Rai, Ranjana; Dippold, Dirk; Roether, Judith E.; Schubert, Dirk W.; Rosellini, Elisabetta; Barbani, Niccoletta; Boccaccını, Aldo R.

doi:10.1016/j.actbio.2014.02.023

Cited by 201 publications

(169 citation statements)

References 50 publications

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“…[18] Conductive polymers have also been incorporated into scaffolds to promote the contraction ability but their compliance (elasticity) after in vivo implantation was not sufficient. [12][13][14] Herein, we report a mussel-inspired conductive cryogel, which could simultaneously address all three aforementioned properties of the ideal cardiac scaffold. Cryogels, which are synthesized by a novel cryogelation technology at sub-zero temperatures, show an interconnected macroporous network and excellent compressing property.…”

Section: Introductionmentioning

confidence: 98%

“…MI also alignment and elongation of the cardiomyocytes, and thus better resisting damage from the beating heart as opposed to stiff scaffolds; [10,11] 2) great affinity and retention for cardiac cells; [12] and 3) synchronous contraction ability to better conduct the bioelectric signals and avoid severe arrhythmia in vivo. [13,14] The majority of current cardiac scaffolds address one or two of the properties listed above, but not all. For instance, the usage of natural polymers (gelatin, [15] alginate, [16] collagen type I, and fibrin [17] ) to develop cardiac patches has emphasized their good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Especially after they have been implanted in vivo, the conductive scaffolds will permit the host heart and the cardiac patch to operate as a unit through the electrical pulse conduction and thus support the reestablishment of a synchronous contraction in the damaged heart. [13] Among the conducting polymers, polypyrrole (Ppy) has often been used in ECPs and has been proven to induce isolated cardiomyocytes by stimulating the expression of the gap junction protein connexin 43 (CX-43), [24,25] as well as enhancing the conduction of the Ca 2+ signal. [26] In order to improve the integrity of the Ppy nanoparticles and the cryogel, we introduced a mussel-inspired dopamine as a crosslinker for the MA-G/PEGDA cryogel.…”

Section: Introductionmentioning

confidence: 99%

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Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Wang

Jiang

Hua

et al. 2016

Adv Funct Materials

157

130

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The engineered cardiac patch (ECP) is a promising strategy to repair infarct myocardium and restore the cardiac function. An ideal ECP should be able to mimic the primary attributes of native myocardium, which includes a high resilience, good cardiomyocyte adhesion, and synchronous contraction. Here, a mussel‐inspired dopamine crosslinker is used to integrate polypyrrole (Ppy) nanoparticles, gelatin‐methyacrylate, and poly(ethylene glycol) diacrylate into a cryogel form. The dopamine crosslinker and Ppy nanoparticles are coordinated to obtain optimal mechanical and superelastic properties for the ECP. The dopamine facilitates the uniform distribution of the Ppy nanoparticles, which migrate and fuse from the scaffold to the surface of the cardiomyocytes, revealing a potential mechanism for restoring infarct myocardium. The incorporated Ppy nanoparticles thus significantly enhance the functionalization of the cardiomyocytes, resulting in excellent synchronous contraction by increasing the expression of α‐actinin and CX‐43. Cardiomyocytes‐loaded ECP can improve the cardiac function in myocardial‐infarction (MI) affected rat models. The results show that the fractional shortening and ejection fraction are elevated by about 50% and that the infarct size is reduced by 42.6%. Collectively, this study highlights an effective cardiac patch based on mussel‐inspired conductive particle adhesion and a superelastic cryogel promising for the restoration of infarcted myocardium.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Wang

Jiang

Hua

et al. 2016

Adv Funct Materials

157

130

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“…[ 33 ] In addition, the introduction of MAAG network can reduce the electrical conductivity of HEDN organogel, the conductivity of PTAA (HEDN 1) organogel is signifi cantly higher than that of ). [ 9,34 ] The conductivity of MAAG single network (HEDN 5) organogel is only (0.23 ± 0.08) × 10 −4 S cm −1 , which is signifi cantly lower than that of HEDN 1-4 organogel ( p < 0.01). It is because the MAAG network could not generate electrical signals by electron transfer.…”

Section: Electrical Properties Of Hedn Hydrogelsmentioning

confidence: 95%

Development of Electrically Conductive Double‐Network Hydrogels via One‐Step Facile Strategy for Cardiac Tissue Engineering

Yang

Yao

Hao

et al. 2015

Adv Healthcare Materials

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Cardiac tissue engineering is an effective method to treat the myocardial infarction. However, the lack of electrical conductivity of biomaterials limits their applications. In this work, a homogeneous electronically conductive double network (HEDN) hydrogel via one-step facile strategy is developed, consisting of a rigid/hydrophobic/conductive network of chemical crosslinked poly(thiophene-3-acetic acid) (PTAA) and a flexible/hydrophilic/biocompatible network of photo-crosslinking methacrylated aminated gelatin (MAAG). Results suggest that the swelling, mechanical, and conductive properties of HEDN hydrogel can be modulated via adjusting the ratio of PTAA network to MAAG network. HEDN hydrogel has Young's moduli ranging from 22.7 to 493.1 kPa, and its conductivity (≈10(-4) S cm(-1)) falls in the range of reported conductivities for native myocardium tissue. To assess their biological activity, the brown adipose-derived stem cells (BADSCs) are seeded on the surface of HEDN hydrogel with or without electrical stimulation. Our data show that the HEDN hydrogel can support the survival and proliferation of BADSCs, and that it can improve the cardiac differentiation efficiency of BADSCs and upregulate the expression of connexin 43. Moreover, electrical stimulation can further improve this effect. Overall, it is concluded that the HEDN hydrogel may represent an ideal scaffold for cardiac tissue engineering.

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“…The synthesized conductive hydrogel was able to improve cell adhesion and proliferation of C2C12 cells and adipose-derived MSCs, resulting in excellent mechanical properties and biocompatibility. Yang et al developed a homogeneous electron conducting dual network (HEDN) consisting of a rigid hydrophobic conductive network of chemically crosslinked poly (thiophene-3-acetic acid) and a flexible hydrophobic network of photographic crosslinking methacrylated aminated gelatin [157]. In this experiment, the Young's modulus of the HEDN conductive hydrogel was adjustable from 22.7 to 493.1 kPa according to the network ratio.…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

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In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

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Development and characterization of novel electrically conductive PANI–PGS composites for cardiac tissue engineering applications

Cited by 201 publications

References 50 publications

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Development of Electrically Conductive Double‐Network Hydrogels via One‐Step Facile Strategy for Cardiac Tissue Engineering

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

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