Development and characterization of newer floating film bearing 5-fluorouracil as a model drug

Bhardwaj, Peeyush; Singh, Ranjit; Swarup, Anoop

doi:10.1016/s1773-2247(14)50092-5

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Cellulose acetate (CA), a water-insoluble excipient used to prepare semi-permeable coatings or matrices for sustained-release tablets, was used by Bhardwaj et al, to obtain floating films loaded with 5-fluorouracil and a gas-forming agent. DF was placed in capsules, after the dissolution of which the films showed an ascent delay time of 85 to 142 s and a flotation time of 17 to 23 h, depending on the composition, providing a delayed release of API [19,61]. Ciprofloxacin microcapsules based on cellulose acetate were prepared by Asa and Mirzaeei by the solvent removal method.…”

Section: Other Semi-synthetic Polymersmentioning

confidence: 99%

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Blynskaya

Tishkov²,

Vinogradov³

et al. 2022

Pharmaceutics

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The combination of targeted transport and improvement of the release profile of the active pharmaceutical ingredient (API) is a current trend in the development of oral medicinal products (MP). A well-known way to implement this concept is to obtain floating gastroretentive delivery systems that provide a long stay of the dosage form (DF) on the surface of the stomach contents. The nomenclature of excipients (Es) of a polymeric nature used in the technology of obtaining floating drug delivery systems (FDDS) is discussed. Based on the data presented in research papers, the most widely used groups of polymers, their properties, and their purpose in various technological approaches to achieving buoyancy have been determined. In addition, ways to modify the release of APIs in these systems and the Es used for this are described. The current trends in the use of polymers in the technology of floating dosage forms (FDF) and generalized conclusions about the prospects of this direction are outlined.

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Section: Other Semi-synthetic Polymersmentioning

confidence: 99%

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

Blynskaya

Tishkov²,

Vinogradov³

et al. 2022

Pharmaceutics

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“…The results were analyzed for mean weight and standard deviation. 8 Average Thickness Digital micrometer screw gauge (Aerospace, China) was used to measure film thickness at different film locations, which are essential to ascertain film thickness uniformity. 9,10 Folding Endurance Evaluation of folding endurance is the study to check the folding capacity of the film when subjected to frequent extreme folding conditions.…”

Section: Weight Uniformitymentioning

confidence: 99%

“…The time taken by the film to come from bottom to top was named as floating lag time, and the duration of time for which the film constantly floated on the surface was noted as total floating time. 8 In-vitro Drug Release Study Each successful film was rolled and placed in a hard gelatin capsule separately. Then, the USP type II apparatus was used to set the metclo release from different formulations.…”

Section: Weight Uniformitymentioning

confidence: 99%

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Preparation and Characterization of Hydroxypropyl methylcellulose Gastroretentive Film using Metoclopramide HCl

Hamdi¹,

Mohamed²,

Mansour³

2022

IJDDT

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This study aimed to formulate a gastro retentive slow release dosage form based on oral film for metoclopramide hydrochloric acid (HCl), a medication with a narrow absorption window. The gastroretentive film was made using a solvent casting method with varying ratios of primary polymers (HPMC 15000 cps and HPMC K4M), secondary polymer (carbopol 934), and PEG-400 as a plasticizer. The film of hydroxypropyl methylcellulose (HPMC) K4M-3 (50:50) (HPMC K4M: carbopol) was buoyant for 20 minutes. The 52 wt % of metoclopramide HCl (metclo) was released from the HPMC K4M-3 film after 24 hours, and its swelling index was (46.5%). The mucoadhesive strength of the HPMC K4M-3 was 18 gm, and the film showed no effect on the rat’s stomach tissue compared to normal rat tissue histologically. The HPMC K4M-3 produced modest values of percent elongation of 77.6%. To conclude, the optimized film appeared to be a promising mucoadhesive gastro retentive oral film with the ease of administration and controlled release.

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“…The oral route is the most accessible and practical way to deliver drugs to patients, and many progressive approaches were practised and studied to serve specific goals ( Jagdale et al 2009 ). A case in point is the gastroretentive delivery system which establishes an extended drug delivery with increased residence time in the stomach ( Kakumanu et al, 2008 , Darandale and Vavia, 2012 , Bhardwaj et al, 2014 , Tripathi et al, 2019 ). This system sets about for drug’s action locally ( Klausner et al, 2003 , Kumar et al, 2008 ) or the drugs that are unstable in the intestinal or colonic environment ( Meka et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%