Development and characterization of new functionalized polyurethanes for sustained and site-specific drug release in the gastrointestinal tract

Campiñez, María Dolores; Benito, Eva; Romero-Azogil, Lucía; Aguilar-de-Leyva, Ángela; Garcı́a-Martı́n, Marı́a de Gracia; Caraballo, Isidoro

doi:10.1016/j.ejps.2017.01.017

Cited by 21 publications

(9 citation statements)

References 31 publications

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“…An homopolyurethane with free secondary hydroxyl groups based on 3,4-O-isopropylidene-D-mannitol and 2,2'-dithiodiethyldiisocyanate has been used as sustained matrix forming excipient for site-specific drug release in the gastrointestinal tract [59].…”

Section: Pu With Enhanced Hydrophilicitymentioning

confidence: 99%

Bio‐Based Polyurethanes from Carbohydrate Monomers

Galbis¹,

Garcı́a-Martı́n²,

de-Paz³

et al. 2017

Aspects of Polyurethanes

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The production of sustainable and environmentally friendly materials constitutes a growing field of attention. The incorporation of sugar-derived units into traditional step-growth polymers such as polyamides, polyesters, and polyurethanes is a healthy method to prepare novel biodegradable and biocompatible materials for application in the biomedical field and other sectors such as foodstuff packaging.

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Section: Pu With Enhanced Hydrophilicitymentioning

confidence: 99%

Bio‐Based Polyurethanes from Carbohydrate Monomers

Galbis¹,

Garcı́a-Martı́n²,

de-Paz³

et al. 2017

Aspects of Polyurethanes

Self Cite

View full text Add to dashboard Cite

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“…Campiñez et al synthesised new biodegradable PUs, containing disulphide bonds, and studied their ability to be used as sustained release excipients for delivery to the colon. 47 The stability of PurSil®AL20 (PUS), a copolymer of HMDI, BD, poly(tetramethylene oxide) (PTMO) and poly(dimethylsiloxane) (PDMS), for use as a vehicle for docetaxel delivery through an oesophageal drug eluting stent (DES) was investigated by Shaikh et al; 48 solid-state behaviour of docetaxel and polymer microstructure were found to affect drug release. Da Silver et al report the successful incorporation or borage oil (containing essential fatty acids for wound healing) into and its release from PU foam wound dressings; the authors also review many other drugs that have been incorporated into such dressings, e.g., analgesics, cicatrizing agents, antibiotics and anti-cancer drugs.…”

Section: Drug Delivery Vehiclesmentioning

confidence: 99%

Biomedical applications of polyurethane materials and coatings

Joseph

Patel

Wenham

et al. 2018

Transactions of the IMF

131

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Polyurethanes (PUs), formed by the reaction of diisocyanates with polyols (or equivalent) in the presence of a catalyst, have a wide variety of industrial uses. Much recent attention has focused on their biomedical applications, owing to their biocompatibility, biodegradability and tailorable chemical and physical forms. Examples of such application areas include antibacterial surfaces and catheters, drug delivery vehicles, stents, surgical dressings/pressure sensitive adhesives, tissue engineering scaffolds and electrospinning, nerve generation, cardiac patches and PU coatings for breast implants. Following a brief introduction to PUs, this review surveys selected articles, mostly from 2014 to 2017, that highlight this diverse range of biomedical applications offered by PU materials and coatings.

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“…And in the same year, SIPOS, et al [24] used SeDeM and SeDeM-ODT Expert System to study ibuprofen ODT tablets in children. And Campiñez, et al [25] used the SeDeM Expert System to test the prescription design of polyurethane, and found that this biodegradable polymer had good fluidity and could be used in direct pressing tablets. Unnecessary excipient screening is reduced.…”

Section: Application Of Sedem Expert System In Pre-formulationmentioning

confidence: 99%

SeDeM Expert System：A review and new perspectives

Sun

Guan

et al. 2019

J Pharm Biopharm Res

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The SeDeM Expert System was first known as a galenic pre-formulation system, which was based on the experimental research and quantitative determination of powdered substances. And the mathematical formula provided by the SeDeM Expert System has plays an important role in the study of powder properties. The system can be used not only to evaluate the powder direct compression (DC) of excipients and active pharmaceutical ingredients (API's), but also to predict the possible formulations, so it can reduce unnecessary research and trials, and shorten the time of development. In this paper, the research development and application of SeDeM Expert System in DC was summarized, and the results showed that with a few exceptions, the system was skilled in predicting acceptable tablet formulations. Finally, the new application prospect of the system is presented, including the application of the Internet traffic and content management (iTCM) database and the new co-processed excipients.

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Development and characterization of new functionalized polyurethanes for sustained and site-specific drug release in the gastrointestinal tract

Cited by 21 publications

References 31 publications

Bio‐Based Polyurethanes from Carbohydrate Monomers

Bio‐Based Polyurethanes from Carbohydrate Monomers

Biomedical applications of polyurethane materials and coatings

SeDeM Expert System：A review and new perspectives

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