Development and Characterization of Nanoparticles for the Delivery of Gemcitabine Hydrochloride

Khaira, Rekha; Sharma, Jyoti; Saini, Vinay

doi:10.1155/2014/560962

Cited by 44 publications

(26 citation statements)

References 16 publications

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“…Our results are in agreement with earlier reports on nanostarch from cassava and curcumin loaded starch nanoparticles . In an earlier study, gemcitabine hydrochloride loaded corn starch nanoparticles were also reported to have similar morphology . The morphological characteristics of cassava starch nanoparticles were found to be similar to that of waxy maize starch nanoparticles prepared by Angellier et al and pea starch nanoparticles prepared by Chen et al .…”

Section: Resultssupporting

confidence: 92%

Cassava starch‐poly(vinyl alcohol) nanocomposites for the controlled delivery of curcumin in cancer prevention and treatment

Athira

Jyothi

2015

Starch Stärke

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Curcumin, a natural yellow pigment with a wide spectrum of bioactivities, was incorporated in nanocomposite films of cassava starch with poly(vinyl alcohol) (PVA) for achieving sustained release properties which improves its potential for use in cancer treatment. The ultra structure of the films was studied by scanning electron microscopy (SEM) and the formation of nanoparticles was confirmed by transmission electron microscopic (TEM) analysis. The curcumin incorporation in the films was confirmed by Fourier transform infra red spectroscopy (FTIR). The swelling capacity and erosion of the films were also recorded. It was observed that pH of the medium and storage conditions greatly affected the release of curcumin from the polymer matrices. The release behaviour of curcumin from starch-PVA matrices was studied and the kinetics behind the curcumin release was fitted to Higuchi model. The mechanism obtained from Korsemeyer-Peppas equation was a combination of diffusion and erosion controlled. Cytotoxicity study of the incorporated curcumin was carried out with normal as well as cancer cells and the results showed that it was non-toxic to normal cells and it also showed anticancer potential. The cell viability (%) in the case of cancer cells was lower for nanocomposite incorporated curcumin than pure curcumin which indicates higher anti cancer potential of the former. The size of curcumin was reduced in the nanocomposites as evidenced from TEM and SEM analysis results, which might have resulted in its greater cell availability and resultant higher anticancer activity.

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Section: Resultssupporting

confidence: 92%

Cassava starch‐poly(vinyl alcohol) nanocomposites for the controlled delivery of curcumin in cancer prevention and treatment

Athira

Jyothi

2015

Starch Stärke

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“…Reaction yield (RY) of the synthesized chitosan–hexaconazole nanoparticles was calculated using Equation 6 [51].…”

Section: Methodsmentioning

confidence: 99%

Preparation of Chitosan–Hexaconazole Nanoparticles as Fungicide Nanodelivery System for Combating Ganoderma Disease in Oil Palm

et al. 2019

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Fungicide is used to control fungal disease by destroying and inhibiting the fungus or fungal spores that cause the disease. However, failure to deliver fungicide to the disease region leads to ineffectiveness in the disease control. Hence, in the present study, nanotechnology has enabled the fungicide active agents (hexaconazole) to be encapsulated into chitosan nanoparticles with the aim of developing a fungicide nanodelivery system that can transport them more effectively to the target cells (Ganoderma fungus). A pathogenic fungus, Ganoderma boninense (G. boninense), is destructive to oil palm whereby it can cause significant loss to oil palm plantations located in the Southeast Asian countries, especially Malaysia and Indonesia. In regard to this matter, a series of chitosan nanoparticles loaded with the fungicide, hexaconazole, was prepared using various concentrations of crosslinking agent sodium tripolyphosphate (TPP). The resulting particle size revealed that the increase of the TPP concentration produced smaller particles. In addition, the in vitro fungicide released at pH 5.5 demonstrated that the fungicide from the nanoparticles was released in a sustainable manner with a prolonged release time up to 86 h. On another note, the in vitro antifungal studies established that smaller particle size leads to lower half maximum effective concentration (EC50) value, which indicates higher antifungal activity against G. boninense.

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“…The reaction yield of the synthesized nanoparticles was calculated using Equation 7 [36]: RY = [Produced nanoparticle (mg)/(used chitosan (mg) + used dazomet (mg))] × 100…”

Section: Methodsmentioning

confidence: 99%

A Potent Antifungal Agent for Basal Stem Rot Disease Treatment in Oil Palms Based on Chitosan-Dazomet Nanoparticles

Maluin

Yusof

Fakurazi

et al. 2019

IJMS

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The use of nanotechnology could play a significant role in the agriculture sector, especially in the preparation of new-generation agronanochemicals. Currently, the economically important plant of Malaysia, the oil palm, faces the threat of a devastating disease which is particularly caused by a pathogenic fungus, Ganoderma boninense. For the development of an effective antifungal agent, a series of chitosan nanoparticles loaded with a fumigant, dazomet, were prepared using various concentrations of sodium tripolyphosphate (TPP)—2.5, 5, 10, and 20 mg/mL, abbreviated as CDEN2.5, CDEN5, CDEN10, and CDEN20, respectively. The effect of TPP as a crosslinking agent on the resulting particle size of the synthesized nanoparticles was investigated using a particle size analyzer and high-resolution transmission electron microscopy (HRTEM). Both methods confirmed that increasing the TPP concentration resulted in smaller particles. In addition, in vitro fumigant release at pH 5.5 showed that the release of the fumigant from the nanoparticles was of a sustained manner, with a prolonged release time up to 24 h. Furthermore, the relationship between the chitosan-dazomet nanoparticles and the in vitro antifungal activity against G. boninense was also explored, where the nanoparticles of the smallest size, CDEN20, gave the highest antifungal efficacy with the lowest half maximum effective concentration (EC50) value of 13.7 ± 1.76 ppb. This indicates that the smaller-sized agronanoparticles were more effective as an antifungal agent. The size can be altered, which plays a crucial role in combatting the Ganoderma disease. The agronanoparticles have controlled release properties and high antifungal efficacy on G. boninense, thus making them a promising candidate to be applied in the field for Ganoderma treatment.

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Development and Characterization of Nanoparticles for the Delivery of Gemcitabine Hydrochloride

Cited by 44 publications

References 16 publications

Cassava starch‐poly(vinyl alcohol) nanocomposites for the controlled delivery of curcumin in cancer prevention and treatment

Cassava starch‐poly(vinyl alcohol) nanocomposites for the controlled delivery of curcumin in cancer prevention and treatment

Preparation of Chitosan–Hexaconazole Nanoparticles as Fungicide Nanodelivery System for Combating Ganoderma Disease in Oil Palm

A Potent Antifungal Agent for Basal Stem Rot Disease Treatment in Oil Palms Based on Chitosan-Dazomet Nanoparticles

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