Development and characterization of murine monoclonal antibodies to first and second Ljungan virus genotypes

Kallies, René; Arbrandt, Gustav; Niklasson, Bo; Niedrig, Matthias

doi:10.1016/j.jviromet.2012.05.001

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Ljungan virus (LV), one species of parechovirus, has emerged in the literature as a putative cause of affictions in animals, and potentially in humans. It can cause not only diabetes, myocarditis, encephalitis and Guillain‐Barre syndrome (Niklasson et al,; Niklasson, ), but also placental inflammation, malformations, and fetal death (Kalliesa et al, ; Niklasson, ; Claudia et al, ). This commentary mainly reviews the literature regarding stillbirth and fetal malformation associated with LV infection in animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation

Zheng

Fang

Huang

et al. 2015

Birth Defects Research Pt C

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More and more epidemiologic and experimental data support the notion that Ljungan virus (LV), originally isolated from some rodent populations in Sweden, Denmark, and the United States, plays an important role in stillbirth and fetal malformation. Mouse dams infected with LV may result in uterine resorption and perinatal deaths that may cross generations, and their offspring may suffer high rates of malformations including cranial, brain, and limb malformations. In humans, researches founded that LV infection is related to malformation, intrauterine fetal death, and even central nervous system malformation. Although molecularly characterized, little is known about the biophysical nature of LV. Consequently, the role of LV infections in sudden infant death syndrome is still confusing, and the mechanism of how LV infections cause diseases is not clear. More research is clearly necessary to explore the mechanisms of LV infection in human and animal diseases to bring improvement to the clinical outcomes.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation

Zheng

Fang

Huang

et al. 2015

Birth Defects Research Pt C

View full text Add to dashboard Cite

show abstract

Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats

et al. 2016

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A picornavirus (Ljungan virus) has been associated with diabetes in its wild rodent reservoir and in diabetes-prone biobreeding (DP-BB) rats. We attempted to alter the development of diabetes in DP-BB rats using two anti-picornavirus compounds (pleconaril and APO-N039), singly or in combination. Antiviral therapy was initiated 2 weeks before expected onset of diabetes. Pleconaril or APO-N039 alone did not affect the debut of diabetes. However, animals receiving a combination of both compounds were protected for at least the entire period of treatment (4 weeks after expected time of diabetes onset). Immunohistochemistry demonstrated that the presence and distribution of virus antigen in the pancreatic islets coincided with the clinical status of the animal. Data indicate that a treatable picornavirus can be involved in the cellular assault resulting in diabetes and in these cases the disease mechanism appears to involve a virus present in the pancreatic beta cell mass itself.

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Development and characterization of murine monoclonal antibodies to first and second Ljungan virus genotypes

Cited by 2 publications

References 40 publications

Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation

Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation

Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats

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