Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Miguez-Pacheco, Valentina; Büttner, Teresa; Maçon, Anthony L. B.; Jones, Julian R.; Fey, Tobias; Ligny, Dominique de; Greil, Peter; Chevalier, Jérôme; Malchère, Annie; Boccaccını, Aldo R.

doi:10.1016/j.jnoncrysol.2015.03.027

Cited by 68 publications

(35 citation statements)

References 35 publications

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“…The literature data on the cytotoxic ions release rates for lithium-substituted HA materials is rather scarce and reported cytotoxic levels are sometimes contradictory due to the fact that release rates are strongly depending on crystallinity or particle morphology and size of the investigated material [42]. In a current study, Miguez-Pacheco et al [64] reported on lithium-containing bioactive glasses, with Li 2 O substituting Na 2 O in different amounts. The conclusion of their study, in terms of lithium ion release, was that formulations with 2.5 wt.% and 5 wt.% Li 2 O content proved to be within the therapeutic range.…”

Section: Biocompatibilitymentioning

confidence: 70%

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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Simple and lithium-doped biological-origin hydroxyapatite layers were synthesized by Pulsed Laser Deposition technique on medical grade Ti substrates. Cytotoxic effects of lithium addition and the biocompatibility of obtained coatings were assessed using three cell lines of human origin (new initiated dermal fibroblasts, immortalized keratinocytes HaCaT, and MG-63 osteosarcoma). Antimicrobial properties of obtained coatings were assessed on two strains (i.e., Staphylococcus aureus and Candida albicans), belonging to species representative for the etiology of medical devices biofilm-associated infections. Our findings suggest that synthesized lithium-doped coatings exhibited low cytotoxicity on human osteosarcoma and skin cells and therefore, an excellent biocompatibility, correlated with a long-lasting anti-staphylococcal and -fungal biofilm activity. Along with low fabrication costs generated by sustainable resources, these biological-derived materials demonstrate their promising potential for future prospective solutions—viable alternatives to commercially available biomimetic HA implants—for the fabrication of a new generation of implant coatings.

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Section: Biocompatibilitymentioning

confidence: 70%

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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“…On the other hand, Li plays a vital role in the proliferation and differentiation of osteoblasts via upregulation of the Wnt pathway, which in turn could enhance osteogenesis and accelerate bone healing in vivo (Khorami, Hesaraki, Behnamghader, Nazarian, & Shahrabi, ). Furthermore, Li has been shown to enhance bone formation while also possessing immune‐stimulating and antimicrobial properties (Kavitha, Subha, Shanmugam, & Kulandaivelu, ; Miguez‐Pacheco et al, ). However, although Sr and Li have been used as doping elements in existing formulations of BGs, the simultaneous incorporation of Sr and Li into a SiO 2 ‐CaO‐P 2 O 5 system has not been explored.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Moghanian

Portillo-Lara

Sani

et al. 2019

J Tissue Eng Regen Med

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Orthopedic surgical procedures based on the use of conventional biological graft tissues are often associated with serious post-operative complications such as immune rejection, bacterial infection, and poor osseointegration. Bioresorbable bone graft substitutes have emerged as attractive alternatives to conventional strategies because they can mimic the composition and mechanical properties of the native bone. Among these, bioactive glasses (BGs) hold great potential to be used as biomaterials for bone tissue engineering owing to their biomimetic composition and high biocompatibility and osteoinductivity. Here, we report the development of a novel composite biomaterial for bone tissue engineering based on the incorporation of a modified strontium-and lithium-doped 58S BG (i.e., BG-5/5) into gelatin methacryloyl (GelMA) hydrogels. We characterized the physicochemical properties of the BG formulation via different analytical techniques. Composite hydrogels were then prepared by directly adding BG-5/5 to the GelMA hydrogel precursor, followed by photocrosslinking of the polymeric network via visible light. We characterized the physical, mechanical, and adhesive properties of GelMA/BG-5/5 composites, as well as their in vitro cytocompatibility and osteoinductivity. In addition, we evaluated the antimicrobial properties of these composites in vitro, using a strain of methicillinresistant Staphylococcus Aureus. GelMA/BG-5/5 composites combined the functional characteristics of the inorganic BG component, with the biocompatibility, biodegradability, and biomimetic composition of the hydrogel network. This novel biomaterial could be used for developing osteoinductive scaffolds or implant surface coatings with intrinsic antimicrobial properties and higher therapeutic efficacy. KEYWORDSantimicrobial, bioactive glass, bioadhesive, bone tissue engineering, orthopedic biomaterials, osteoinductive *These authors contributed equally to this work.

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“…Although lithium did not seem to alter the glass structure, a low lithium content (3 and 7 wt%) inhibited the formation of hydroxyapatite on the glass upon immersion in SBF. Similar compositions were made into porous scaffolds by Miguez-Pacheco et al using foam replica techniques [10,11]. Lithium has also been incorporated into ordered mesoporous sol-gel glass scaffolds (Li-MBG, 80 mol% SiO 2 ; 10 mol% CaO, 5 mol% P 2 O 5 and 5 mol% Li 2 O) [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li 2 O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 29 Si and 7 Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.Graphical Abstract

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Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair

Cited by 68 publications

References 35 publications

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

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