Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine
M. Alagusundaram,
Nem Kumar Jain,
M. Yasmin Begum
et al.
Abstract:A promising controlled drug delivery system has been developed based on polymeric buccoadhesive bilayered formulation that uses a drug-free backing layer and a polymeric hydrophilic gel buccoadhesive core layer containing nifedipine. The DSC thermogravimetric analysis confirms the drug’s entrapment in the gel layer and reveals no evidence of a potential interaction. Various ratios of bioadhesive polymers, including HPMC K100, PVP K30, SCMC, and CP 934, were combined with EC as an impermeable backing layer to e… Show more
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