Development and Characterization of Chitosan Cross-Linked With Tripolyphosphate as a Sustained Release Agent in Tablets, Part I: Design of Experiments and Optimization

Pinto, Colin; Saripella, Kalyan K.; Loka, Nikhil C.; Neau, Steven H.

doi:10.1016/j.xphs.2017.11.018

Cited by 13 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of chemical crosslinkers is known to improve the stability of CS against pH, temperature variations, and biological and mechanical degradation, while allowing to modulate structure and properties of the CS gel network [14,[28][29][30][31][32][33][34]. In fact, by controlling the extent of chemical crosslinking of CS, it is possible to constraint important features of CS-based materials such as size, which may range from nanoparticles to macroscopic gels or films, or the extent of association and release of bioactive payloads of interest [31,32,[35][36][37][38][39][40][41][42][43]. Genipin (GNP) is a natural crosslinking agent obtained from the glycosylated geniposide iridoid compound produced by the fruits of Gardenia jasminoides and Genipa americana.…”

Section: Introductionmentioning

confidence: 99%

Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities

Vila-Sanjurjo

David

Remuñán‐López

et al. 2019

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities

Vila-Sanjurjo

David

Remuñán‐López

et al. 2019

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

“…Cross-linked chitosan was investigated as sustained release agent in tablets. In granular form, particles of CHI crosslinked with tripolyphosphate exbibited some limitations like inefficient drug loading and incomplete release [ 28 ]. Associated with anionic polymers (i.e.…”

Section: Introductionmentioning

confidence: 99%

Self-stabilized chitosan and its complexes with carboxymethyl starch as excipients in drug delivery

Leonida

Ispas‐Szabo

Mateescu

2018

Bioactive Materials

View full text Add to dashboard Cite

This study focuses on the behavior of chitosan (CHI) and its polyelectrolyte complexes with carboxymethyl starch (CMS) used as monolithic matrices with acetaminophen as drug tracer. Two different chitosan grades were tested alone or associated in various ratios with CMS as excipients for tablets obtained by direct compression. The degree of deacetylation (DDA) of CHI, estimated from 1H NMR and FTIR data, was correlated with X-ray diffraction and scanning electron microscopy (SEM) to evaluate structural organization of the monolithic matrices. In vitro drug dissolution assays showed major differences in CHI kinetic profiles between tablets exposed to acidic medium for 2h (to mimick gastric passage) prior to dissolution in simulated intestinal fluid (SIF), and those administered directly to SIF. Prior exposure to acidic SGF conducted to longer dissolution profiles (release completed after 16 h) and preservation of tablet shape, whereas tablets directly incubated in SIF were rapidly disintegrated. The improved properties of chitosan matrices exposed to SGF may be related to an outer compact coating layer (visible in SEM). The effect of self-stabilization of chitosan in acidic medium was compared to that due to formation of polyelectrolyte complexes (PEC) in co-processed polymeric systems (CHI:CMS). The self-formed membrane following exposure to gastric acidity appears to help maintaining tablet integrity and allows higher drug loading, recommending CHI and its complexes with CMS as excipients for drug delivery.

show abstract

Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology

et al. 2018

View full text Add to dashboard Cite

A statistical approach with D‐optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C‐110°C), time (1‐7 h), mixing speed (50‐500 rpm) and monomer/solvent ratio (1:1‐1:6). Molecular weight was chosen as response and was determined using matrix‐assisted laser desorption/ionization time of flight (MALDI TOF). Using the D‐optimal method in design of experiments, the interactions between parameters and responses were analysed and validated. The results show a good agreement with a minimum error between the actual and predicted values.

show abstract

Development and Characterization of Chitosan Cross-Linked With Tripolyphosphate as a Sustained Release Agent in Tablets, Part I: Design of Experiments and Optimization

Cited by 13 publications

References 49 publications

Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities

Effect of the ultrastructure of chitosan nanoparticles in colloidal stability, quorum quenching and antibacterial activities

Self-stabilized chitosan and its complexes with carboxymethyl starch as excipients in drug delivery

Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology

Contact Info

Product

Resources

About