Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Mishra, Rakesh K.; Mondal, Subhadip; Datt, M.; Banthia, A. K.

doi:10.1007/s12588-009-0018-y

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…2θ=21 °) with higher intensity (as a result of crystalline phase), indicating that addition of GA increases the crystallinity of chitosan. Similar findings were observed by Mishra et al., 51 where chitosan–phosphomolybdic acid based films crosslinked with GA showed higher crystallinity percentage in comparison to pure chitosan. The peaks recorded for the Ch(2.0)–GA ( x = 0.45) microparticles with encapsulated polyphenols were of the greatest intensity; similarly, Hosseini et al.…”

Section: Resultssupporting

confidence: 90%

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties

et al. 2015

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Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on water and polyphenols transport properties was investigated. Swelling ratio of dry particles (68-230 µm) in water ranged from 280% to 530%, depending on the formulation. The decrease in swelling was observed with increased GA/Ch mass ratio (i.e. crosslinking degree) at the same chitosan concentration, or with increased chitosan concentration at the same GA/Ch mass ratio. The increase in GA/Ch mass ratio was also manifested by increased particle compactness i.e. decreased size and reduced surface roughness. The sorption capacity for polyphenols seems to be a complex interplay of swelling behaviour and interactions chitosan-glutaraldehyde-polyphenols identified by Fourier transmission infrared analysis. An increase in crystallinity of chitosan was observed upon crosslinking with glutaraldehyde and encapsulation of polyphenols, as observed by X-ray diffraction analysis. The results obtained from release kinetics of selected polyphenolic compounds (caffeic acid, rosmarinic acid, total flavonoids, and total phenol content) showed that polyphenols were released at a lower amount (2-4 times) in water, but more rapidly (45-120 min) in comparison with the release in gastric followed by intestinal simulated fluid (SGF-SIF) (120-240 min). The experimental results of the time-dependent swelling in water and polyphenols release in both, water and SGF-SIF, were analyzed with several mathematical models. The results depicted Fickian diffusion as the water transport mechanism. In the case of polyphenols, only empirical Weibull model could be suggested for describing release kinetics.

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Section: Resultssupporting

confidence: 90%

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties

et al. 2015

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“…In this temperature the peak of water evaporation contained in chitosan can be observed. The peak near 180°C may be the glass transition peak of pure chitosan [25]. After addition of tannic acid, the glass transition temperature increased, what confirms possible molecular interactions between chitosan and tannic acid.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 72%

The influence of UV-irradiation on chitosan modified by the tannic acid addition

Sionkowska

Kaczmarek

Gnatowska

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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“…PVP also has characteristics peaks at these positions, which mean that the PVP peaks overlapped the CS peaks. The small sharp peak at 35.87° also showed the semi‐crystalline nature of CS . Two crystalline peaks (α and β) of CS confirm the crystalline nature of CS with monoclinic symmetry .…”

Section: Resultsmentioning

confidence: 70%

Hybrid cross‐linked hydrogels as a technology platform forinvitrorelease of cephradine

Gull

Khan

Butt

et al. 2019

Polymers for Advanced Techs

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Hydrogel-based drug delivery systems can leverage therapeutically favorable upshots of drug release and found clinical uses. Hydrogels offer temporal and spatial control over the release of different therapeutic agents. Because of their tailor made controllable degradability, physical properties, and ability to prevent the labile drugs from degradation, hydrogels provide platform on which diverse physicochemical interactions with entrapped drugs cause to control drug release. Herein, we report the fabrication of novel vinyltrimethoxy silane (VTMS) cross-linked chitosan/polyvinyl pyrrolidone hydrogels. Swelling in distilled water in conjunction with different buffer and electrolyte solutions was performed to assess the swellability of hydrogels.Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and X-ray diffraction (XRD) analysis were further conducted to investigate the possible interactions between components, thermal stability, and crystallinity of asprepared hybrid hydrogels, respectively. In vitro time-dependent biodegradability, antimicrobial study, and cytotoxicity were also carried out to evaluate their extensive biocompatibility and cytotoxic behavior. More interestingly, in vitro drug release study allowed for the controlled release of cephradine. Therefore, this facile strategy developed the novel biocompatible and biodegradable hybrid hydrogels, which could significantly expand the scope of these hydrogels in other biomedical applications like scaffolds, skin regeneration, tissue engineering, etc.

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Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Cited by 12 publications

References 19 publications

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties

The influence of UV-irradiation on chitosan modified by the tannic acid addition

Hybrid cross‐linked hydrogels as a technology platform forinvitrorelease of cephradine

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