Development and Characterization of Bioadhesive Film Embedded with Lignocaine and Calcium Fluoride Nanoparticles

Ghafar, Hira; Khan, Muhammad Imran; Sarwar, Hafiz Shoaib; Yaqoob, Samiya; Hussain, Syed Zajif; Tariq, Imran; Madni, Asad Ullah; Shahnaz, Gul; Sohail, Muhammad

doi:10.1208/s12249-019-1615-5

Cited by 30 publications

(28 citation statements)

References 30 publications

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“…[ 80,82,83 ] A daily intake of 200 ppm of fluoride has been shown to prevent dental caries. [ 85 ] To maintain the concentration of fluoride ions in the salvia, researchers have resorted to designing novel ion delivery systems that offer sustained ion release.…”

Section: Ion Deliverymentioning

confidence: 99%

“…The results suggest that these nanoparticles are capable of releasing fluoride ions in an acidic environment and expedite hard tissue remineralization. [ 90 ] Calcium fluoride and lignocaine nanoparticles have been loaded in thiolated chitosan bioadhesive films for prolonged release of fluoride ions over 8 h. [ 85 ] Recently, NaF nanoparticles have been prepared in the presence of surfactant and loaded on a polylactic acid nanoscaffold using electrospinning for delivery of fluoride ions to dentin ( Figure A). The nanoparticles ranged between 80 and 110 nm with the polylactic acid scaffold (Figure 8B,C).…”

Section: Ion Deliverymentioning

confidence: 99%

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Ion Deliverymentioning

confidence: 99%

Section: Ion Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…Examples of bioadhesive polymers include chitosan, dextran and polyacrylic acid [100]. Nanoparticles can be delivered directly into the periodontal pocket or loaded into films which can be inserted into the periodontal pocket [101]. In relation to the treatment of periodontitis, polymeric nanoparticles and metallic nanoparticles are among the most explored materials to achieve drug delivery and immuno-modulation, as well as antimicrobial action.…”

Section: Antimicrobial Nanoparticle-based Strategiesmentioning

confidence: 99%

“…Calcium fluoride nanoparticles, synthesized due to their higher deposition of fluoride on the tooth and adsorption onto the biofilm, were further loaded together with lignocaine into mucoadhesive films made from thiolated chitosan for prolonged retention of the nanoparticles in the oral cavity. This system was successfully prepared demonstrating suitable mechanical strength, bioadhesion, drug release and permeation enhancement [101]. Echazú et al reported the development of pH-responsive biopolymer composites, composed of silica nanoparticles in chitosan hydrogels [128].…”

Section: Polymeric Nanoparticles For Drug Delivery and Immunomodulationmentioning

confidence: 99%

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

et al. 2021

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The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

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“…The microorganisms present in the oral cavity promote sugar metabolism generating acidic metabolites that drastically reduce the osral pH [ 10 , 11 ]. The acidification of the pH starts the process of demineralization of the teeth, that leads to the loss of calcium, fluoride, and phosphate ions, resulting in the formation of cavities [ 12 ].…”

Section: Dental Cariesmentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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Development and Characterization of Bioadhesive Film Embedded with Lignocaine and Calcium Fluoride Nanoparticles

Cited by 30 publications

References 30 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

Nanoparticles in Dentistry: A Comprehensive Review

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