Development and characterization of alginate-derived crosslinked hydrogel membranes incorporated with ConA and gentamicin for wound dressing applications.

Macedo, Gustavo Henrique Rodrigues Vale de; Chagas, Vitor Lopes; Santos, Maria Helena Cruz dos; Santos, Gabrielle Damasceno Costa dos; Bazán, José Manuel Noguera; Zagmignan, Adrielle; Carvalho, Edilausson Moreno; Miranda, Rita de Cássia Mendonça de; Teixeira, Claudener S.; Silva, Luís Cláudio Nascimento da

doi:10.1016/j.bej.2022.108664

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…As a common medicine applied in wound management, antibiotics are widely used to prevent infection and purulent discharge in some injuries, such as extensive burns, diabetic ulcers, and postoperative wounds. 44 However, treatment with antibiotics also leads to side effects, especially the loss of the normal microbiota in the human body. At present, the therapeutic efficacy of using exogenous probiotics in therapy should be considered with caution.…”

Section: In Vivo Wound Healing Ability Of the Hydrogelsmentioning

confidence: 99%

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Zhou

Zou

et al. 2023

Mater. Horiz.

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Section: In Vivo Wound Healing Ability Of the Hydrogelsmentioning

confidence: 99%

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Zhou

Zou

et al. 2023

Mater. Horiz.

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“…6,7 The conventional wound dressings tended to adhere to the wound with poor barrier effect and were prone to exogenous infections, which can lead to delayed wound healing. 8,9 The introduction of natural drugs can effectively enhance the antibacterial properties of polymer nanofibers. Different from conventional dressings, bioactive wound dressings can be absorbed by the body and promote wound healing because of their good biocompatibility, bioactivity, and ease of biochemical functionalization.…”

mentioning

confidence: 99%

Antibacterial activity and sustained release properties of curcumin-loaded chitosan microspheres/nanofiber composites membranes for wound healing applications

Zhang

et al. 2023

Textile Research Journal

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The application of bioactive curcumin is limited due to its poor stability, lower absorption, and fast metabolism in the human body. In the present study, chitosan/curcumin microspheres were prepared by reverse emulsion polymerization and electrospun with polyvinyl alcohol to fabricate chitosan/curcumin microspheres with polyvinyl alcohol composite nanofibrous membranes. The fiber morphology of chitosan/curcumin microspheres/polyvinyl alcohol composite nanofibrous membranes was observed by scanning electron microscopy, indicating that there are more continuous and uniform fibers of chitosan/curcumin microspheres/polyvinyl alcohol than those without chitosan/curcumin microspheres. Fourier transform infrared spectroscopy was applied to test the chemical structural changes of nanofibrous membranes, which showed that chitosan/curcumin microspheres were physically mixed with polyvinyl alcohol. The mechanical properties of the samples were tested by an electronic fabric strength machine and the tensile strength of the composite nanofibrous membranes can reach 7.e Mpa. The introduced drug release profiles indicated that after 60 h of culturing, the release rate of composite nanofibrous membranes was 69.8%. The bacterial inhibition rate of the composite nanofibrous membranes was assessed through the oscillation method. The results obtained revealed that the bacterial inhibition rate of chitosan/curcumin microspheres/polyvinyl alcohol composite nanofibers was detected up to 99.9% in the 48 h antimicrobial test.

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Fabrication and characterization of physically crosslinked alginate/chitosan-based hydrogel loaded with neomycin for the treatment of skin infections caused by Staphylococcus aureus

Silva,

Vila Nova,

Sousa

et al. 2024

International Journal of Biological Macromolecules

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Development and characterization of alginate-derived crosslinked hydrogel membranes incorporated with ConA and gentamicin for wound dressing applications.

Cited by 6 publications

References 46 publications

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

Antibacterial activity and sustained release properties of curcumin-loaded chitosan microspheres/nanofiber composites membranes for wound healing applications

Fabrication and characterization of physically crosslinked alginate/chitosan-based hydrogel loaded with neomycin for the treatment of skin infections caused by Staphylococcus aureus

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