Abstract:For the precise visualization of GPCR, subtype selectivity
of turn-on
fluorescent ligands is of major relevance. Although there are many
thriving β-adrenergic receptors (β-ARs) probes, none of
them are selective to the β3-subtype, which severely
limits the development of β3-AR investigations. Using
a polyethylene glycol (PEG) chain to conjugate the Py-5 fluorophore
with mirabegron, we present here a highly selective fluorescent ligand, H2, for β3-AR. It was established by the
radioligand and NanoLuc-based biol… Show more
“…24,25 In comparison, detections based on "turn-on" luminescence are more desirable because they show better accuracy by reducing the influence of many quenching species. 26,27 Herein, dual emission carbon dots (N-CDs) were synthesized for separately detecting HClO and Cys by virtue of 'ratiometric' and 'turn-on' fluorescence responses. As shown in Scheme 1, the N-CDs show two fluorescence emission peaks at 548 and 640 nm.…”
Abnormal levels of HClO and cysteine (Cys) are associated with some diseases, so it is of great importance to detect them accurately. In this work, new carbon dots N-CDs for...
“…24,25 In comparison, detections based on "turn-on" luminescence are more desirable because they show better accuracy by reducing the influence of many quenching species. 26,27 Herein, dual emission carbon dots (N-CDs) were synthesized for separately detecting HClO and Cys by virtue of 'ratiometric' and 'turn-on' fluorescence responses. As shown in Scheme 1, the N-CDs show two fluorescence emission peaks at 548 and 640 nm.…”
Abnormal levels of HClO and cysteine (Cys) are associated with some diseases, so it is of great importance to detect them accurately. In this work, new carbon dots N-CDs for...
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