Development and characterization of a hydrogel-based adhesive patch for sealing open-globe injuries

Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

“…Current biomaterials that devoted to corneal sealing and repair include synthetic materials, such as the cyanoacrylate glues, polyethylene glycol (PEG)-based hydrogels, and diverse natural materials (collagen, fibrin, gelatin, alginate, etc.) [ 17 , 18 ]. Cyanoacrylate glue has been used in off-label clinical ophthalmology for years [ 19 , 20 ], but it has obvious disadvantages, including opaque rough surface, rapid polymerization, and high cytotoxicity.…”

A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair

“…The temperature dependent viscosity and shear‐thickening behavior of GelMA at room temperature and lower temperatures has also been shown in previous studies, [ 17,18 ] which is not desirable for injection in clinical settings. This was the main reason that GelMA was combined with hyaluronic acid or chitosan to tailor its viscosity, [ 19 ] while the LC‐COMatrix does not need supplemental materials since it is a natural combination of collagen and sGAGs. [ 13a ]…”

“…In addition to GelMA, [ 7,19a ] a fibrin‐based biomaterial has been introduced for in situ repair of corneal stromal defects. [ 9a ] Like GelMA, this fibrin‐based product needs preapplication warming and requires mixing of the prepolymer with cross‐linker prior to application.…”

“…The temperature dependent viscosity and shear-thickening behavior of GelMA at room temperature and lower temperatures has also been shown in previous studies, [17,18] which is not desirable for injection in clinical settings. This was the main reason that GelMA was combined with hyaluronic acid or chitosan to tailor its viscosity, [19] while the LC-COMatrix does not need supplemental materials since it is a natural combination of collagen and sGAGs. [13a] A descriptive experiment was performed to evaluate the behavior of LC-COMatrix compared to cyanoacrylate, fibrin glue, ViscoElastic, and 20% GelMA (37 °C) while applied to an ex vivo human cornea in an upright position.…”

A starch-regulated adhesive hydrogel dressing with controllable separation properties for painless dressing change

“…9,10 Hydrogels can adhere to skin tissue through a variety of non-covalent interactions and covalent bonds. [11][12][13][14] For example, the polar groups contained in gelatin, 15 fibrin glue 16 and cyanoacrylate 17 can quickly form strong intermolecular van der Waals force, thus making the hydrogel stick to human tissue in a few seconds. With the introduction of chitosan, 18,19 alginate 20 and hyaluronic acid, 21 the resulting hydrogels are closely adhered to tissues through amide bonds.…”