Development and characterization of a biocompatible OH‐modified copolymer based on polyurethane

Abstract

Different polyurethanes were synthesized by varying the diol as well as the diisocyanate components and chain extenders. Polyurethanes with OH-groups were obtained by photo-and thermoinitiation of the radical polymerization of hydroxy alkyl acrylates in the presence of the polyurethanes. The polymers were evaluated with respect to their biocompatibility by measuring the cell spreading, the rates of DNA-and protein synthesis and the swelling behaviour. The differences in the surfaces and the bulks between the selected basic polyurethane and the functionalized modification were determined and characterized by XPS, FTIR-ATR and '3C-FT-NMR-spectroscopy.The mechanical data of Tecof lex EG 60D @ and Pellethane 2363-80AE @ were compared with the data of the synthesized polyurethanes.

Generating hydrophilic surfaces on standard polymers after copolymerization with low amounts of protected vinyl sugars

“…Copolymers of styrene with 3 or 4 and with free hydroxyl groups at the surface have a surface resistance of 10 10 X/cm and are thus already approaching the region of antistatic polymers 20) . X-ray photoelectron spectroscopy (XPS) has long been used for characterizing polymer surfaces and the modification of polymer surfaces, such as new chemical structures introduced by plasma 21) , UV 12) , additives 22) , and surface grafting 23) . Polymers having pendant saccharides were investigated by Nakamae et al using XPS recently 14,15) .…”

“…Zhang and Rånby modified PET fibers by a photoinitiated graft copolymerization of acrylic acid or acrylamide onto the surface 11) . Höcker et al grafted 2-hydroxyethyl methacrylate (HEMA) on polyurethane 12) . Kiyotsukuri et al prepared PET copolymers with 2,2-dialkyl-1,3-propanediols which increased the dyeability of PET 13) .…”

Polymers for Biomedical Applications: Improvement of the Interface Compatibility

“…The immobilized 4-amino-TEMPO leads to an ESR signal characterized by reduced molecular motion in comparison with an uncoupled spin probe as a control sample [133]. Consequently, the modified PCU/PVA surface is suitable for the immobilization of the fibronectin fragment GRGDS via the N -terminus [147].…”

“…catheters, heart valves [47]. A poly(carbonate urethane) (PCU) comprising poly(hexamethylene carbonate), the aromatic diisocyanate 4,4'-diphenylmethane diisocyanate (MDI) and 1,4-butanediol as chain prolonger has been developed ( Table 2) [133].…”

“…Benzoquinone was bound to the surface of a poly(carbonate urethane) modified with poly(4-hydroxybutyl acrylate) (PCU/HBA) and to the vinyl acetate grafted and saponified poly(ether urethane) (Mitrathane) (PEU/VA-plasma) [136][137][138][139]. Aliphatic dicarboxylic acid dichlorides were applied to the surface-saponified blend of 50 wt% poly(ethylene-co-propene) and 50 wt% poly(ethylene-co-vinyl acetate) (PP/EVA).…”