Development and characterization of a fucoidan-based nanoemulsion using Nigella sativa oil for improvement of anti-obesity activity of fucoxanthin in an obese rat model

Oliyaei, Najme; Tanideh, Nader; Moosavi‐Nasab, Marzieh; Dehghanian, Amir Reza; Iraji, Aida

doi:10.1016/j.ijbiomac.2023.123867

Cited by 12 publications

(4 citation statements)

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“…Furthermore, fucoidan and zein exhibited typical bands at 3454 cm −1 and 3335 cm −1 , respectively, indicative of O–H stretching vibration. Remarkably, these wavenumbers basically aligned with previously reported findings 31,46,52 . For the pure zein, the shifts of the O–H stretching vibration band and the amide II band in blank zein/fucoidan nanoparticles implied potential hydrogen bond formation and electrostatic interaction forces between zein and fucoidan 15,31 …”

Section: Resultssupporting

confidence: 89%

“…Remarkably, these wavenumbers basically aligned with previously reported findings. 31,46,52 For the pure zein, the shifts of the O-H stretching vibration band and the amide II band in blank zein/fucoidan nanoparticles implied potential hydrogen bond formation and electrostatic interaction forces between zein and fucoidan. 15,31 The blank nanoliposomes spectrum revealed distinct peaks: 1735 cm −1 representing C=O symmetrical stretching vibration, 2925 cm −1 and 2852 cm −1 denoting the symmetric and antisymmetric CH 2 stretching vibrations of the acryl chain, 25 1085 cm −1 and 1242 cm −1 associated with the symmetric and asymmetric stretching vibration of PO 2− , 18,53 and 1465 cm −1 assigned to the asymmetric stretching vibration of CH 3 .…”

Section: Ftir Analysis Of Nanoparticlesmentioning

confidence: 99%

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Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Chen,

Wang,

et al. 2024

J Sci Food Agric

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BACKGROUNDTo improve phytol bioavailability, a novel method of magnetic stirring and high‐pressure homogenization (HPH) combination was used to prepare zein/fucoidan‐coated phytol nanoliposomes (P‐NL‐ZF). The characterization, the simulated in vitro digestion, and the antioxidant activity of these phytol nanoliposomes from the different processes have been studied.RESULTSBased on the results of dynamic light scattering (DLS) and gas chromatography–mass spectrometer (GC–MS) analysis, P‐NL‐ZF prepared through the combination of magnetic stirring and HPH exhibited superior encapsulation efficiency at 76.19% and demonstrated exceptional physicochemical stability under a series of conditions, including storage, pH, and ionic in comparison to single method. It was further confirmed that P‐NL‐ZF by magnetic stirring and HPH displayed a uniform distribution and regular shape through transmission electron microscopy (TEM). Fourier‐transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) analysis showed that electrostatic interactions and hydrogen bonding were the primary driving forces for the formation of composite nanoliposomes. Additionally, an in vitro digestion study revealed that multilayer composite nanoliposomes displayed significant and favorable slow‐release properties (58.21%) under gastrointestinal conditions compared with traditional nanoliposomes (82.36%) and free phytol (89.73%). The assessments of chemical and cell‐based antioxidant activities demonstrated that the coating of zein/fucoidan on phytol nanoliposomes resulted in enhanced effectiveness in scavenging activity of ABTS free radical and hydroxyl radical and mitigating oxidative damage to HepG2 cells.CONCLUSIONBased on our studies, the promising delivery carrier of zein/fucoidan‐coated nanoliposomes is contributed to the encapsulation of hydrophobic natural products and enhancement of their biological activity. © 2024 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 89%

Section: Ftir Analysis Of Nanoparticlesmentioning

confidence: 99%

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Chen,

Wang,

et al. 2024

J Sci Food Agric

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“…Over time, the beneficial effects of postoperative changes in gastrointestinal hormones may gradually diminish or be counteracted by other pathways [20]. Additionally, consistent with previously published data [21], severe impairments in liver metabolic function and lipid metabolism were observed in obese rats, which were significantly alleviated by SG. Indeed, the protective effects of SG against obesity have been reported in several studies [22][23][24], Endocrine Journal Advance Publication further confirming our findings in the present study.…”

Section: Discussionsupporting

confidence: 83%

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Li,

Qiao,

Wang

et al. 2024

Endocr J

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Obesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been widely used to treat obesity and its complications, showing promising results. However, it remains unclear whether SG can alleviate obesity-induced cardiac dysfunction. A sudden decline in body weight and food intake was observed in both the obese and obese + SG groups, with a higher rate of increase observed in the Obese group. Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. Lastly, the increased levels of relative proteins observed in obese rats were significantly reduced by SG. In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.

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“…Among various natural products, it is well known that marine and algal bioactive compounds are utilized for prevention and treatment of bacterial biofilm (Melander et al, 2020). Algae are known as renewable sources of bioactive compounds, in particular, carotenoids and polysaccharides, with a wide range of biological activities, such as antioxidant, antimicrobial, antiinflammatory, anti-obesity, antidiabetic, anticancer, and anti-Alzheimer activities (Oliyaei et al, 2023). Macroalgae or seaweeds are classified into Chlorophyceae (green algae), Phaeophyceae (brown algae), and Rhodophyceae (red algae) .…”

Section: Introductionmentioning

confidence: 99%

Anti-biofilm activity of marine algae-derived bioactive compounds

Behzadnia,

Moosavi-Nasab,

Oliyaei

2024

Front. Microbiol.

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A large number of microbial species tend to communicate and produce biofilm which causes numerous microbial infections, antibiotic resistance, and economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes and targets, such as quorum sensing communication system. Meanwhile, quorum sensing inhibitors as promising anti-biofilm molecules result in the inhibition of particular phenotype expression blocking of cell-to-cell communication, which would be more acceptable than conventional strategies. Many natural products are identified as anti-biofilm agents from different plants, microorganisms, and marine extracts. Marine algae are promising sources of broadly novel compounds with anti-biofilm activity. Algae extracts and their metabolites such as sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin and lutein), lipid and fatty acids (γ-linolenic acid and linoleic acid), and phlorotannins can inhibit the cell attachment, reduce the cell growth, interfere in quorum sensing pathway by blocking related enzymes, and disrupt extracellular polymeric substances. In this review, the mechanisms of biofilm formation, quorum sensing pathway, and recently identified marine algae natural products as anti-biofilm agents will be discussed.

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Development and characterization of a fucoidan-based nanoemulsion using Nigella sativa oil for improvement of anti-obesity activity of fucoxanthin in an obese rat model

Cited by 12 publications

References 60 publications

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Anti-biofilm activity of marine algae-derived bioactive compounds

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