Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery

Rai, Dinesh; Maniruzzaman, Mohammed; Boateng, Joshua

doi:10.1504/ijbt.2010.036594

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…Recent years have seen similar studies carried out by many other workers [93] – [96] . Table 1 showcases some of the most worked upon APIs in the field of MBDDS along with the polymers associated, and Table 2 enlists some commercially available dosage forms meant to be applied in the buccal cavity along with their therapeutic application.…”

Section: A Clinical/therapeutic Approachsupporting

confidence: 76%

A clinical perspective on mucoadhesive buccal drug delivery systems

Gilhotra¹,

Ikram²,

Srivastava³

et al. 2014

J Biomed Res

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Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for extended periods of time by the help of interfacial forces. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form. The objective of this paper is to review the works done so far in the field of mucoadhesive buccal drug delivery systems (MBDDS), with a clinical perspective. Starting with a brief introduction of the mucoadhesive drug delivery systems, oral mucosa, and the theories of mucoadhesion, this article then proceeds to cover the works done so far in the field of MBDDS, categorizing them on the basis of ailments they are meant to cure. Additionally, we focus on the various patents, recent advancements, and challenges as well as the future prospects for mucoadhesive buccal drug delivery systems.

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Section: A Clinical/therapeutic Approachsupporting

confidence: 76%

A clinical perspective on mucoadhesive buccal drug delivery systems

Gilhotra¹,

Ikram²,

Srivastava³

et al. 2014

J Biomed Res

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“…In addition, % elongation at break represents the strain magnitude responsible for the film elongation. 19 Remarkably, polymeric films manifest an opposite relationship between tensile strength and % elongation. Hence, applying the tensile strength test to evaluate the film's elasticity is important in the integrity of the film that is favorable to be intact one piece.…”

Section: Tensile Strengthmentioning

confidence: 99%

Preparation and Characterization of Hydroxypropyl methylcellulose Gastroretentive Film using Metoclopramide HCl

Hamdi¹,

Mohamed²,

Mansour³

2022

IJDDT

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This study aimed to formulate a gastro retentive slow release dosage form based on oral film for metoclopramide hydrochloric acid (HCl), a medication with a narrow absorption window. The gastroretentive film was made using a solvent casting method with varying ratios of primary polymers (HPMC 15000 cps and HPMC K4M), secondary polymer (carbopol 934), and PEG-400 as a plasticizer. The film of hydroxypropyl methylcellulose (HPMC) K4M-3 (50:50) (HPMC K4M: carbopol) was buoyant for 20 minutes. The 52 wt % of metoclopramide HCl (metclo) was released from the HPMC K4M-3 film after 24 hours, and its swelling index was (46.5%). The mucoadhesive strength of the HPMC K4M-3 was 18 gm, and the film showed no effect on the rat’s stomach tissue compared to normal rat tissue histologically. The HPMC K4M-3 produced modest values of percent elongation of 77.6%. To conclude, the optimized film appeared to be a promising mucoadhesive gastro retentive oral film with the ease of administration and controlled release.

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“…Modified forms of such hydrogel polymers with better bioadhesivity create second-generation mucosal dosage forms [9]. In the present study, we report on the development of solvent cast films for buccal delivery in paediatric patients using various hydrogel polymers generally regarded as safe (GRAS) and used in mucosal formulations [10][11][12][13] including HPMC, MC, CA, MET, SA, plasticiser (PEG 400), OME (model drug) and L-arg (to stabilise OME). Various parameters such as drying times and temperatures, casting solvents as well as polymer and plasticiser concentrations were investigated and the films subsequently characterised as part of the development and optimisation.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Characterisation and Stabilisation of Buccal Films for Paediatric Drug Delivery of Omeprazole

et al. 2015

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Abstract. This study aimed to develop films for potential delivery of omeprazole (OME) via the buccal mucosa of paediatric patients. Films were prepared using hydroxypropylmethylcellulose (HPMC), methylcellulose (MC), sodium alginate (SA), carrageenan (CA) and metolose (MET) with polyethylene glycol (PEG 400) as plasticiser, OME (model drug) and L-arg (stabiliser). Gels (1% w/w) were prepared at 40°C using water and ethanol with PEG 400 (0-1% w/w) and dried in an oven (40°C). Optimised formulations containing OME and L-arg (1:1, 1:2 and 1:3) were prepared to investigate the stabilisation of the drug. Tensile properties (Texture analysis, TA), physical form (differential scanning calorimetry, DSC; X-ray diffraction, XRD; thermogravimetric analysis, TGA) and surface topography (scanning electron microscopy, SEM) were investigated. Based on the TA results, SA and MET films were chosen for OME loading and stabilisation studies as they showed a good balance between flexibility and toughness. Plasticised MET films were uniform and smooth whilst unplasticised films demonstrated rough lumpy surfaces. SA films prepared from aqueous gels showed some lumps on the surface, whereas SA films prepared from ethanolic gels were smooth and uniform. Drug-loaded gels showed that OME was unstable and therefore required addition of L-arg. The DSC and XRD suggested molecular dispersion of drug within the polymeric matrix. Plasticised (0.5% w/w PEG 400) MET films prepared from ethanolic (20% v/v) gels and containing OME: L-arg 1:2 showed the most ideal characteristics (transparency, ease of peeling and flexibility) and was selected for further investigation.

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Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery

Cited by 9 publications

References 9 publications

A clinical perspective on mucoadhesive buccal drug delivery systems

A clinical perspective on mucoadhesive buccal drug delivery systems

Preparation and Characterization of Hydroxypropyl methylcellulose Gastroretentive Film using Metoclopramide HCl

Formulation, Characterisation and Stabilisation of Buccal Films for Paediatric Drug Delivery of Omeprazole

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